Female choice and variation in the major histocompatibility complex.
Female choice and variation in the major histocompatibility complex.
复制标题
主要组织相容性复合体的女性选择和变异。
DOI：
10.1093/genetics/132.2.575
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发表时间：
1992
期刊：
影响因子：
3.3
通讯作者：
Hedrick,PW
中科院分区：
文献类型：
--
作者：
Hedrick,PW
主要组织相容性复合体（MHC）的高遗传变异性的原因尚不完全清楚。最近，有两个报告表明，雌性小鼠更喜欢与MHC上与它们不同的雄性小鼠交配。在这里开发一个适合这些观察的女性选择模型。事实上，雌性选择可以减少观察到的纯合子比例，保持遗传多态性，影响交配型频率和产生配子不平衡。
The cause of the high genetic variability in the major histocompatibility complex (MHC) is not entirely clear. Recently, two reports suggest that female mice prefer to mate with males different from them at the MHC. A model of female choice appropriate for those observations is developed here. Female choice can in fact reduce the observed proportions of homozygotes, maintain genetic polymorphism, influence mating-type frequencies and generate gametic disequilibrium.