Endothelial progenitor cells for postnatal vasculogenesis.
Endothelial progenitor cells for postnatal vasculogenesis.
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DOI：
10.1007/s10157-006-0448-1
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发表时间：
2007-03-01
影响因子：
2.3
通讯作者：
Asahara, Takayuki
中科院分区：
文献类型：
--
作者：
Eguchi, Masamichi;Masuda, Haruchika;Asahara, Takayuki
骨髓来源的内皮祖细胞存在于全身循环中，在某些细胞因子和/或组织缺血时被增强，是新生血管的所在地，也是新生血管的结合部位。综上所述，内皮祖细胞作为一种以细胞为基础的新策略，主要通过血管生成机制，在心血管缺血性疾病的治疗方面具有潜在的应用前景。这篇综述提供了内皮祖细胞生物学的最新进展，并强调了这些细胞在治疗再生中的潜在用途。
Bone marrow-derived endothelial progenitor cells (EPCs) are present in the systemic circulation, are augmented in response to certain cytokines and/or tissue ischemia, and are home to--as well as incorporate into--sites of neovascularization. On the basis of these aspects, EPCs have attractive potential therapeutic applications for cardiovascular ischemic diseases as a novel cell-based strategy, mainly via a vasculogenesis mechanism. This review provides an update of the biology of EPCs, as well as highlighting the potential use of these cells for therapeutic regeneration.