ANTINEOPLASTIC AGENTS .256. CELL-GROWTH INHIBITORY ISOCARBOSTYRILS FROM HYMENOCALLIS
ANTINEOPLASTIC AGENTS .256. CELL-GROWTH INHIBITORY ISOCARBOSTYRILS FROM HYMENOCALLIS
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DOI：
10.1021/np50100a004
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发表时间：
1993-10-01
影响因子：
5.1
通讯作者：
MEEROW, AW
中科院分区：
文献类型：
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作者：
PETTIT, GR;PETTIT, GR;MEEROW, AW
在夏威夷采集并在亚利桑那州园艺种植的Hymenocallis littoralis 的球茎，以及在新加坡采集的Hymenocallis caribaea 和Hymenocallis latifolia 的球茎，被发现含有细胞毒性的异喹诺酮型生物合成产物，7-脱氧-反式-二氢水仙素 [2]。这种新化合物抑制多种病毒的细胞病变和/或复制。 H. littoralis 和 Hymenocallis sp. 的伴随细胞毒性成分。被发现是 pancratistatin [1)、narciclasine [5] 和 7-deoxynarciclasine [4)。这四种化合物以及其他四种密切相关的化合物在国家癌症研究所的体外细胞毒性小组中进行了比较评估。尽管总体效力存在显着差异，但其中一些化合物针对 NCI 组中的 60 种不同的人类谣言细胞系具有高度特征性的差异细胞毒性特征。作为一个组，黑色素瘤亚面板线最敏感；其他子面板中的某些单独线（例如，NSC 肺、结肠、脑、肾）的敏感性比不太敏感的线高出千倍之多。
The bulbs of Hymenocallis littoralis, collected in Hawaii and horticulturally grown in Arizona, and bulbs of Hymenocallis caribaea and Hymenocallis latifolia, collected in Singapore, were found to contain a cytotoxic, isocarbostyril-type biosynthetic product, 7-deoxy-trans-dihydronarciclasine [2]. This new compound inhibited the cytopathicity and/or replication of various viruses. Companion cytotoxic constituents of H. littoralis and Hymenocallis sp. were found to be pancratistatin [1), narciclasine [5], and 7-deoxynarciclasine [4). These four compounds, along with four other closely related compounds, were comparatively evaluated in the National Cancer Institute's in vitro cytocoxicity panel. Although there were striking differences in overall potency, some of the compounds shared a highly characteristic differential cytotoxicity profile against the 60 diverse human rumor cell lines comprising the NCI panel. As a group, the melanoma subpanel lines were most sensitive; certain individual lines within other subpanels (eg., NSC lung, colon, brain, renal) were as much as a thousand-fold of more sensitive than the less sensitive lines.