Hemiplegic atrophy
Hemiplegic atrophy
复制标题
偏瘫萎缩
作者：
R. Scelsi;S. Lotta;G. Lommi;P. Poggi;C. Marchetti
应用酶组织化学和电镜技术对16例大脑中动脉区脑血管意外患者的偏瘫侧胫前肌活检标本进行了定性和定量分析，（1-17个月）显示纤维直径逐渐减小，纤维类型分布发生变化，主要为II型萎缩和I型优势。细胞核内化、肌病改变和束周脂肪浸润持续存在。在受累纤维中，超微结构表现为肌原纤维改变，形成杆状体和胞浆体。存在脂褐素、糖原和脂滴的积聚。微血管的变化是经常观察到的。无症状的腿活检是正常的或显示与年龄相关的肌肉改变。相关性之间的临床和功能状态的患者和肌肉活检中看到的形态学方面。
SummaryAnterior tibial muscle biopsies of the hemiplegic side of 16 patients with a cerebrovascular accident in the middle cerebral artery region were analyzed qualitatively and quantitatively by enzyme histochemistry and electron microscopy.Patients grouped according to the time lapsed as from the occurrence of the accident (1–17 months) demonstrated a progressive decrease in the fiber diameter and changes in fiber type distribution with predominant type II atrophy and type I predominance. Nuclear internalization, myopathic alterations, and perifascicular fatty infiltrations were observed constantly.In the affected fibers the ultrastructural findings were myofibrillar alterations with the formation of rods and cytoplasmic bodies. There was accumulation of lipofuscin, glycogen, and lipid droplets. Microvascular changes were observed frequently.Biopsies from the asymptomatic legs were either normal or showed age-related muscle alterations.Correlation was noted between the clinical and functional status of the patients and the morphological aspects seen in muscle biopsies.