Primate Spatial Memory Cells Become Tuned Early and Lose Tuning at Cell-Specific Times.
Primate Spatial Memory Cells Become Tuned Early and Lose Tuning at Cell-Specific Times.
复制标题
灵长类空间记忆细胞很早就进行了调谐，并在细胞特定的时间失去了调谐。
DOI：
10.1093/cercor/bhab079
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Snyder,LawrenceH
中科院分区：
文献类型：
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作者：
Papadimitriou,Charalampos;Holmes,CharlesD;Snyder,LawrenceH
工作记忆是维持和转换信息的能力，对认知起着至关重要的作用。空间工作记忆研究得特别好。空间记忆的首要模型是连续吸引子网络，它假定细胞在记忆期间保持恒定的活动。替代模型提出了导致各种细胞活动时间过程的复杂动力学。我们记录了2只猕猴的额叶眼野和背外侧前额叶皮层的神经元在长（5-15秒）的记忆期间。我们发现，记忆细胞在刺激呈现后早期开启，在不同的固定时间内维持活动，然后关闭并在记忆期的剩余时间内保持关闭。这些动力学比规范碰撞吸引子网络模型的动力学（衰减或非衰减）更复杂，但比完全异构的内存模型的动力学更受约束。我们推测，记忆可能是由多个吸引子网络并行工作，每个网络都有自己的特征平均关闭时间，使记忆资源逐渐释放随着时间的推移。
Working memory, the ability to maintain and transform information, is critical for cognition. Spatial working memory is particularly well studied. The premier model for spatial memory is the continuous attractor network, which posits that cells maintain constant activity over memory periods. Alternative models propose complex dynamics that result in a variety of cell activity time courses. We recorded from neurons in the frontal eye fields and dorsolateral prefrontal cortex of 2 macaques during long (5–15 s) memory periods. We found that memory cells turn on early after stimulus presentation, sustain activity for distinct and fixed lengths of time, then turn off and stay off for the remainder of the memory period. These dynamics are more complex than the dynamics of a canonical bump attractor network model (either decaying or nondecaying) but more constrained than the dynamics of fully heterogeneous memory models. We speculate that memory may be supported by multiple attractor networks working in parallel, with each network having its own characteristic mean turn-off time such that mnemonic resources are gradually freed up over time.