Mechanical properties and osteoconductivity of porous bioactive titanium
Mechanical properties and osteoconductivity of porous bioactive titanium
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DOI：
10.1016/j.biomaterials.2005.03.019
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发表时间：
2005-10-01
期刊：
影响因子：
14
通讯作者：
Nakamura, T
中科院分区：
文献类型：
--
作者：
Takemoto, M;Fujibayashi, S;Nakamura, T
采用喷塑法制备多孔生物活性钛植入物（孔隙率为40%），并对其进行化学和热处理处理，即在5 M NaOH水溶液中60℃浸泡24 h，在40℃蒸馏水中浸泡48 h，然后加热至600℃加热1 h。抗压强度和抗弯强度分别为280 MPa（0.2%补偿屈服强度85.2 MPa）和101 MPa。为了进行体内分析，将生物活性和未经处理的多孔钛柱植入兔股骨髁直径6 mm的孔中。在种植后的所有时间内，生物活性种植体（BGs）的骨与种植体的接触百分比（亲和力指数）显著大于未处理的种植体（CGs）（分别在2、4、8和16周时为13.5比10.5,16.7比12.7,17.7比10.2,19.1比7.8）。BGs的骨面积长入百分比显著增加，而CGs的骨面积长入百分比在4周后出现下降（分别在2、4、8和16周时，10.7 vs . 9.9, 12.3 vs . 13.1, 15.2 vs . 9.8, 20.6 vs . 8.7）。这些结果表明多孔生物活性钛具有足够的力学性能和生物相容性，可以在负重条件下用于临床。(c) 2005 Elsevier Ltd版权所有。
Porous bioactive titanium implants (porosity of 40%) were produced by a plastria-spray method and subsequent chemical and thermal treatments of immersion in a 5 M aqueous NaOH solution at 60 degrees C for 24 h, immersion in distilled water at 40 degrees C for 48 h, and heating to 600 degrees C for 1 h. Compression strength and bending strength were 280 MPa (0.2% offset yield strength 85.2 MPa) and 10 1 MPa, respectively. For in vivo analysis, bioactive and nontreated porous titanium cylinders were implanted into 6 mm diameter holes in rabbit femoral condyles. The percentage of bone-implant contact (affinity index) of the bioactive implants (BGs) was significantly larger than for the nontreated implants (CGs) at all postimplantation times (13.5 versus 10.5, 16.7 versus 12.7, 17.7 versus 10.2, 19.1 versus 7.8 at 2, 4, 8 and 16 weeks, respectively). The percentage of bone area ingrowth showed a significant increase with the BGs, whereas with the CGs it appeared to decrease after 4 weeks (10.7 versus 9.9, 12.3 versus 13.1, 15.2 versus 9.8, 20.6 versus 8.7 at 2, 4, 8 and 16 weeks, respectively). These results suggest that porous bioactive titanium has sufficient mechanical properties and biocompatibility for clinical use under load-bearing conditions. (c) 2005 Elsevier Ltd. All rights reserved.