Vitamin D: current status and perspectives
Vitamin D: current status and perspectives
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DOI：
10.1515/cclm.2009.036
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发表时间：
2009-02-01
影响因子：
6.8
通讯作者：
Souberbielle, Jean-Claude
中科院分区：
文献类型：
--
作者：
Cavalier, Etienne;Delanaye, Pierre;Souberbielle, Jean-Claude
维生素D在维持骨骼健康方面的作用几十年来一直为人所知。然而，最近发现许多组织表达维生素D受体，并能够将25-OH维生素D转化为其最活跃的代谢物1,25-(OH)(2)维生素D，这为这种“老”分子带来了一个非常有希望的未来。事实上，观察性研究和越来越多的干预性研究都在提高维生素D补充的重要性，这不仅对骨骼有益。其中，25-OH维生素D已被发现在预防癌症、自身免疫性疾病、心血管疾病、糖尿病和感染方面发挥重要作用。维生素D缺乏症，定义为血清25-OH维生素D水平< 30 ng/mL，在我们的人群中很常见。成本/效益比和最近发表的一些研究都清楚地表明，在25-OH维生素D水平< 30 ng/mL的患者中，需要控制和有效地补充维生素D。还应更多地关注孕妇和哺乳期妇女以及儿童和青少年。
The role of vitamin D in maintaining bone health has been known for decades. Recently, however, the discovery that many tissues expressed the vitamin D receptor and were able to transform the 25-OH vitamin D into its most active metabolite, 1,25-(OH)(2) vitamin D, has led to a very promising future for this "old'' molecule. Indeed, observational studies, and more and more interventional studies, are raising the importance of a significant vitamin D supplementation for not-only skeletal benefits. Among them, 25-OH vitamin D has been found to play an important role in prevention of cancers, auto-immune diseases, cardiovascular diseases, diabetes, and infections. Vitamin D deficiency, defined as serum 25-OH vitamin D levels < 30 ng/mL, is very common in our population. The cost/benefit ratio and some recently published studies are clearly now in favor of a controlled and efficient vitamin D supplementation in these patients presenting a 25-OH vitamin D level < 30 ng/mL. More attention should also be focused on pregnant and lactating women, as well as children and adolescents.