Intra-articular corticosteroid treatment in osteoarthritis.
Intra-articular corticosteroid treatment in osteoarthritis.
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DOI：
10.1097/00002281-199909000-00016
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发表时间：
1999-09-01
影响因子：
5.1
通讯作者：
Creamer, P
中科院分区：
文献类型：
--
作者：
Creamer, P
关节内皮质类固醇仍然广泛用于周围关节骨关节炎（OA）的对症治疗。几项针对膝关节炎的研究表明，与安慰剂相比，该药有显著的益处，尽管效果似乎仅持续1至3周。两项安慰剂对照研究证实了这些发现。一项进一步的非对照研究检查了髋关节关节内皮质类固醇的作用。人们越来越关注类固醇在OA中的可能的疾病调节作用。虽然在一些动物模型中可以证明有益的效果，但在推断到人体软骨时应谨慎行事。骨关节炎越来越被认为是一种阶段性疾病，其中器官损伤是间歇性发生的。检测疾病活动性增加的这些阶段的能力，可能会通过新的成像或生化技术，导致在OA中使用关节内类固醇的更合理的方法。
Intra-articular corticosteroids remain widely used for symptomatic treatment of peripheral joint osteoarthritis (OA). Several studies in knee OA have indicated a significant benefit compared with placebo, although the effect appears to last for only 1 to 3 weeks. Two placebo-controlled studies have confirmed these findings. A further uncontrolled study has examined the effect of intra-articular corticosteroid at the hip. Attention is increasingly focused on a possible disease-modifying role for steroids in OA. Although a beneficial effect can be demonstrated in some animal models, caution should be exercised when extrapolating to human cartilage. Osteoarthritis is increasingly viewed as a phasic condition in which organ damage occurs intermittently. An ability to detect these phases of increased disease activity, perhaps with new imaging or biochemical techniques, could lead to a more rational approach to the use of intra-articular steroids in OA.