A microstructural analysis of schedule-induced polydipsia reveals incentive-induced hyperactivity in an animal model of ADHD.
A microstructural analysis of schedule-induced polydipsia reveals incentive-induced hyperactivity in an animal model of ADHD.
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对日程诱发的烦渴的微观结构分析揭示了 ADHD 动物模型中激励诱发的多动症。
DOI：
10.1016/j.bbr.2014.10.022
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发表时间：
2015
影响因子：
2.7
通讯作者：
Sanabria,Federico
中科院分区：
文献类型：
--
作者：
Íbias,Javier;Pellón,Ricardo;Sanabria,Federico
最近的研究表明，频繁的短暂活动是与注意缺陷多动障碍（ADHD）相关的多动的特征。本研究确定这种模式是否也可见于自发性高血压大鼠（SHR），ADHD的动物模型中的时间表诱导的烦渴（SIP）。雄性SHR，Wistar京都（WKY）和Wistar大鼠暴露于40个会话的SIP使用多个固定时间（FT）的时间表的食物交付FT 30-s和FT 90-s组件。稳定的性能进行了分析，以确定在何种程度上SIP相关的饮酒是有组织的较量。将自由操作行为的双指数不应期模型（BERM）应用于时间表诱导的舔。模型比较分析支持BERM作为SIP事件的描述：舔不是以恒定的速率产生的，而是在饮酒事件中组织成回合。FT 30-s诱导了相似的总体舔率、从舔到第一次舔的时间和各品系的发作持续时间; FT 90-s诱导了SHR中较长的发作持续时间，并将WKY和Wistar大鼠的舔率降低至接近基线水平。在整个时间表中，与其他菌株相比，SHR的发作次数更多，时间更短。这些结果表明，在操作行为和ADHD儿童中观察到的SHR中的激励诱导的多动。
Recent research has suggested that frequent short bursts of activity characterize hyperactivity associated with attention deficit hyperactivity disorder (ADHD). This study determined whether such pattern is also visible in schedule-induced polydipsia (SIP) in the spontaneously hypertensive rat (SHR), an animal model of ADHD. Male SHR, Wistar Kyoto (WKY) and Wistar rats were exposed to 40 sessions of SIP using a multiple fixed-time (FT) schedule of food delivery with FT 30-s and FT 90-s components. Stable performance was analyzed to determine the extent to which SIP-associated drinking is organized in bouts. The Bi-Exponential Refractory Model (BERM) of free-operant performance was applied to schedule-induced licks. A model comparison analysis supported BERM as a description of SIP episodes: licks were not produced at a constant rate but organized into bouts within drinking episodes. FT 30-s induced similar overall licking rates, latencies to first licks and episode durations across strains; FT 90-s induced longer episode durations in SHRs and reduced licking rate in WKY and Wistar rats to nearly baseline levels. Across schedules, SHRs made more and shorter bouts when compared to the other strains. These results suggest an incentive-induced hyperactivity in SHR that has been observed in operant behaviour and in children with ADHD.