REDUCTION OF PLASMA-CHOLESTEROL LEVELS IN NORMAL MEN ON AN AMERICAN-HEART-ASSOCIATION STEP-1 DIET OR A STEP-1 DIET WITH ADDED MONOUNSATURATED FAT
REDUCTION OF PLASMA-CHOLESTEROL LEVELS IN NORMAL MEN ON AN AMERICAN-HEART-ASSOCIATION STEP-1 DIET OR A STEP-1 DIET WITH ADDED MONOUNSATURATED FAT
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DOI：
10.1056/nejm199003013220902
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发表时间：
1990-03-01
影响因子：
158.5
通讯作者：
DELL, RB
中科院分区：
文献类型：
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作者：
GINSBERG, HN;BARR, SL;DELL, RB
如何设计饮食以达到最佳的血脂水平变化是有争议的。在一项涉及36名健康年轻男性的随机双盲试验中，我们评估了美国心脏协会第1步饮食（其中30%的总热量消耗为脂肪，10%的饱和脂肪，10%的单不饱和脂肪和10%的多不饱和脂肪，每天250毫克胆固醇）和单不饱和脂肪富集的第1步饮食(38%的热量消耗为脂肪；10%的饱和脂肪，18%的单不饱和脂肪，10%的多不饱和脂肪，每天250毫克的胆固醇)。然后将这些饮食的效果与美国人的平均饮食进行比较，美国人的平均饮食中，38%的总热量是脂肪消耗的：18%是饱和脂肪，10%是单不饱和脂肪，10%是多不饱和脂肪，每天含有500毫克胆固醇。这些人吃了10周的美国平均饮食，然后随机分配到两种步骤1饮食中的一种，或者继续平均饮食10周。热量摄入被调整以保持恒定的体重。与平均值相比（+-）。在整个研究过程中，遵循美国平均饮食的一组血浆总胆固醇水平的变化(-0.05。0.36 mmol / l)，第一步饮食组的血浆总胆固醇水平（-0.37 .+- -）有统计学意义的降低（P < 0.025）。0.27毫摩尔/升)，而单不饱和脂肪丰富的第一步饮食组(-0.46。0.36毫摩尔每升)。在这两组中，血浆低密度脂蛋白胆固醇水平有相似的降低。血浆甘油三酯水平和高密度脂蛋白胆固醇浓度在任何饮食中都没有显著变化。我们得出结论，在第1步饮食中添加单不饱和脂肪不会改变第1步饮食对血浆脂质浓度的有益影响。
The design of diets to achieve optimal changes in plasma lipid levels is controversial. In a randomized, double-blind trial involving 36 healthy young men, we evaluated the effects on plasma lipid levels of both an American Heart Association Step 1 diet (in which 30 percent of the total calories were consumed as fat; 10 percent saturated, 10 percent mononusaturated, and 10 percent polyunsaturated fats, with 250 mg of cholesterol per day) and a mononusaturated fat-enriched Step 1 diet (with 38 percent of the calories consumed as fat; 10 percent saturated, 18 percent mononusaturated, and 10 percent polyunsaturated fats, with 250 mg of cholesterol per day). The effects of these diets were then compared with those of an average American diet, in which 38 percent of the total calories were consumed as fat: 18 percent saturated, 10 percent monounsaturated, and 10 percent polyunsaturated fats, with 500 mg of cholesterol per day. The men consumed the average American diet for 10 weeks before random assignment to one of the two Step 1 diets or to continuation of the average diet for an additional 10 weeks. Caloric intake was adjusted to maintain a constant body weight. As compared with the mean (.+-. SD) change in the plasma total cholesterol level in the group that followed the average American diet throughout the study (-0.05 .+-. 0.36 mmol per liter), there were statistically significant reductions (P < 0.025) in the plasma total cholesterol level in the group on the Step 1 diet (-0.37 .+-. 0.27 mmol per liter) and in the group on the mononusaturated fat-enriched Step 1 diet (-0.46 .+-. 0.36 mmol per liter). There were parallel reductions in the plasma low-density lipoprotein cholesterol levels in these two groups. Neither the plasmal triglyceride levels nor the high-density lipoprotein cholesterol concentration changed significantly with any diet. We conclude that enrichment of the Step 1 diet with monounsaturated fat does not alter the beneficial effects of the Step 1 diet on plasma lipid concentrations.