Metformin, an old drug, brings a new era to cancer therapy.
Metformin, an old drug, brings a new era to cancer therapy.
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二甲双胍，一种老药，给癌症治疗带来了新时代。
DOI：
10.1097/ppo.0000000000000103
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Luo Z
中科院分区：
文献类型：
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作者：
He H;Ke R;Lin H;Ying Y;Liu D;Luo Z
二甲双胍是治疗2型糖尿病最常用的处方药，因为它价格便宜，安全，在改善高血糖和高胰岛素血症方面有效。流行病学和临床观察研究表明，二甲双胍的使用降低了2型糖尿病患者的癌症风险，并改善了癌症患者的预后和生存率。此外，正在进行的二甲双胍用于癌症治疗的临床试验正在扩展到非糖尿病人群。因此，二甲双胍正在成为一种有吸引力的癌症预防和治疗候选药物。本文综述了二甲双胍在癌症中应用的最新研究进展，并讨论了提高其疗效和防止肿瘤转移的可能性。
Metformin is the most commonly prescribed drug for type 2 diabetes mellitus as it is inexpensive, safe, and efficient in ameliorating hyperglycemia and hyperinsulinemia. Epidemiological and clinical observation studies have shown that metformin use reduces risk of cancer in patients with type 2 diabetes mellitus and improves prognosis and survival rate of the cancer patients. Furthermore, ongoing clinical trials of metformin in cancer therapy are extending to nondiabetic population. Thus, metformin is emerging as an attractive candidate for cancer prevention and treatment. This review summarizes recent progress in studies of metformin use in cancer and discusses the possibility to enhance its efficacy and to prevent cancer metastasis.