Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles
复制标题
DOI：
10.1016/j.bmcl.2012.02.035
复制
发表时间：
2012-05-01
影响因子：
2.7
通讯作者：
Munoz, Benito
中科院分区：
文献类型：
--
作者：
Youngsaye, Willmen;Dockendorff, Chris;Munoz, Benito
继续努力发现抗击白色念珠菌对氟康唑耐药性的新方法，已经确定了一种吲哚衍生物，它能使对氟康唑耐药的菌株增敏。这个四环(3，ML229)似乎不像酿酒酵母模型中所确定的那样，通过已建立的Hsp90或钙调神经磷酸酶途径作用于白色念珠菌，并可能成为发现替代耐药途径的有用探针。(C)2012爱思唯尔有限公司。保留所有权利。
Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways. (C) 2012 Elsevier Ltd. All rights reserved.