Ocular surface inflammation is regulated by innate immunity
Ocular surface inflammation is regulated by innate immunity
复制标题
DOI：
10.1016/j.preteyeres.2012.05.003
复制
发表时间：
2012-11-01
影响因子：
17.8
通讯作者：
Kinoshita, Shigeru
中科院分区：
文献类型：
--
作者：
Ueta, Mayumi;Kinoshita, Shigeru
在眼表面，如在肠和气道中，表面上皮作为粘膜先天免疫系统的前线防御发挥关键作用。虽然微生物的检测可以说是免疫系统的最重要的任务，一个夸张的上皮宿主防御反应内源性细菌可能会启动和延续炎症mucosal responses.In这篇综述中，我们首先描述眼表，这是在接触眼表上皮细胞上发现的细菌。我们还讨论了眼表上皮细胞的先天免疫，我们提出了眼表上皮细胞调节的过敏反应。我们解决眼表炎症由于先天免疫紊乱，我们提出我们的假设，史蒂文斯-约翰逊综合征（SJS）的发病与严重的眼表并发症，一个毁灭性的眼表炎症性疾病，眼表炎性疾病与先天免疫系统异常密切相关，本文就眼表炎性疾病与先天免疫系统紊乱的可能性进行综述关注眼表的先天免疫可能有助于阐明各种眼表疾病的发病机制。(c)2012爱思唯尔有限公司保留所有权利。
On the ocular surface, as in the intestines and airway, the surface epithelium serves a critical function as the front-line defense of the mucosal innate immune system. Although the detection of microbes is arguably the most important task of the immune system, an exaggerated epithelial host defense reaction to endogenous bacteria may initiate and perpetuate inflammatory mucosal responses.In this review we first describe commensal bacteria found on the ocular surface, which is in contact with the ocular surface epithelium. We also discuss the innate immunity of the ocular surface epithelium and we present the allergic reaction regulated by ocular surface epithelial cells. We address ocular surface inflammation due to disordered innate immunity and we present our hypothesis that the onset of Stevens-Johnson syndrome (SJS) with severe ocular surface complications, a devastating ocular surface inflammatory disease, is strongly associated with abnormality of the innate immune system.In this review we raise the possibility that some ocular surface inflammatory diseases are pathogenetically related with a disordered innate immune response.Focusing on the innate immunity of the ocular surface might help to elucidate the pathogenesis of various ocular surface diseases. (c) 2012 Elsevier Ltd. All rights reserved.