Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder
Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder
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DOI：
10.1039/c8gc02036a
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发表时间：
2018-09-07
期刊：
影响因子：
9.8
通讯作者：
Browne, Duncan L.
中科院分区：
文献类型：
--
作者：
Cao, Qun;Howard, Joseph L.;Browne, Duncan L.
本文讨论了将机械化学混炼机的固相合成反应转化为连续双螺杆挤出机的研究。该研究强调了一些考虑因素，并在模型的反应，这是第一个有机的有机的尝试使用挤出的背景下进行测试的参数。在优化后，其特征在于首次使用研磨辅助固体以实现有效的合成挤出，双螺杆反应被成功地转移到挤出机，导致时空产率（STY）提高100倍;从混合机中的29 kg m（-3）天（-1）到双螺杆挤出机中的3395 kg m（-3）天（-1）。
A study on the translation of a solid-state synthetic reaction from a mechanochemical mixer-mill to a continuous twin-screw extruder is discussed herein. The study highlights some considerations to be made and parameters to be tested in the context of a model fluorination reaction, which is the first organic fluorination to be attempted using extrusion. Upon optimization, which features the first use of grinding auxiliary solids to enable effective synthetic extrusion, the difluorination reaction was successfully translated to the extruder, leading to a 100-fold improvement in Space Time Yield (STY); 29 kg m(-3) day(-1) in a mixer mill to 3395 kg m(-3) day(-1) in a twin screw extruder.