Development of a real-time corneal birefringence compensated glucose sensing polarimeter
Development of a real-time corneal birefringence compensated glucose sensing polarimeter
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DOI：
10.1089/dia.2006.8.156
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发表时间：
2006-04-01
影响因子：
5.4
通讯作者：
Anumula, Harini
中科院分区：
文献类型：
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作者：
Cameron, Brent D.;Anumula, Harini
背景资料：众所周知，为了最佳地管理糖尿病，建议每天监测血糖水平几次，以便可以采取适当的措施将这些水平维持在接近正常的生理范围内。一种显示出希望的技术是使用光学偏振测定法。该技术具有非侵入性地测量与血糖浓度相关的眼睛中的生理葡萄糖水平的潜力。迄今为止，限制体内偏振葡萄糖测量的主要因素是角膜双折射，其往往掩盖葡萄糖特征。在这项研究中，证明了一种补偿角膜双折射影响的方法，从而允许在具有随时间变化的双折射贡献的样品中进行偏振葡萄糖测量。在本文中，使用定制设计的基于激光的光学偏振测量系统与集成双折射补偿器，在生理范围内的无创葡萄糖测量可以在结构与眼睛相似的各种双折射样品中准确测量。使用基于激光的偏振方法，它表明，在生理范围内的葡萄糖水平，在存在显着变化的双折射可以准确地预测低至13.84 mg/dL的error.Conclusions：补偿角膜双折射效应的能力提供了一个商业家庭为基础的非侵入性偏振葡萄糖监测的最终发展的承诺。
Background: As is well known, in order to optimally manage diabetes mellitus, monitoring blood glucose levels several times daily is recommended so appropriate actions can be taken to maintain these levels within a near-normal physiologic range. One technique that shows promise is the use of optical polarimetry. This technique has the potential to noninvasively measure physiological glucose levels in the eye that are correlated to blood glucose concentrations. To date, the main factor limiting in vivo polarimetric glucose measurements is corneal birefringence, which tends to mask the glucose signature. In this investigation, a method to compensate for the effects of corneal birefringence is demonstrated, thus allowing for polarimetric glucose measurements in samples with time-varying birefringence contributions.Methods: In this paper, using a custom-designed laser-based optical polarimetry system with an integrated birefringence compensator, noninvasive glucose measurements in the physiological range are accurately measured within various birefringent samples similar in structure to the eye.Results: Using the laser-based polarimetric approach, it is shown that glucose levels within the physiological range in the presence of significant varying birefringence can be accurately predicted with as low as 13.84 mg/dL error.Conclusions: The ability to compensate for corneal birefringence effects provides promise for the eventual development of a commercial home-based noninvasive polarimetric glucose monitor.