Region of interest-based versus whole-lung segmentation-based approach for MR lung perfusion quantification in 2-year-old children after congenital diaphragmatic hernia repair
Region of interest-based versus whole-lung segmentation-based approach for MR lung perfusion quantification in 2-year-old children after congenital diaphragmatic hernia repair
复制标题
DOI：
10.1007/s00330-016-4330-6
复制
发表时间：
2016-12-01
影响因子：
5.9
通讯作者：
Neff, K. W.
中科院分区：
文献类型：
--
作者：
Weis, M.;Sommer, V.;Neff, K. W.
基于感兴趣区（ROI）入路的2岁儿童先天性膈疝（CDH）后，与对侧相比，同侧MR肺灌注值降低。本研究评估了全肺分割是否可以再现结果，以及基于roi的测量与全肺测量之间是否存在差异。应用动态对比增强（DCE） MRI对30例患儿CDH修复后的肺血流量（PBF）、肺血容量（PBV）和平均传递时间（MTT）进行定量分析。基于roi的量化结果（每肺侧5个相邻切片生成6个圆柱形roi）和全肺分割方法进行了比较。两种入路的同侧PBF和PBV均显著降低（p均< 0.0001）。在同侧肺中，基于roi的入路与基于全肺分段的入路PBF相等（p=0.50）。在对侧肺中，与全肺分割入路相比，基于roi的入路显著高估了PBF约9.5% （p=0.0013）。2岁儿童CDH后MR肺灌注在同侧显著降低。在对侧肺中，基于roi的入路明显高估了灌注，这可以通过排除肺的大部分腹侧部分来解释。因此，应优先选择全肺分割。在同侧全肺分析中，CDH后的绝对肺灌注减少。同样，基于ROI的方法和基于全肺的方法产生相同的结果。对侧，基于roi的方法显著高估了灌注结果。磁共振肺灌注成像应分析全肺。磁共振肺灌注测量是肺功能的无辐射参数。
With a region of interest (ROI)-based approach 2-year-old children after congenital diaphragmatic hernia (CDH) show reduced MR lung perfusion values on the ipsilateral side compared to the contralateral. This study evaluates whether results can be reproduced by segmentation of whole-lung and whether there are differences between the ROI-based and whole-lung measurements.Using dynamic contrast-enhanced (DCE) MRI, pulmonary blood flow (PBF), pulmonary blood volume (PBV) and mean transit time (MTT) were quantified in 30 children after CDH repair. Quantification results of an ROI-based (six cylindrical ROIs generated of five adjacent slices per lung-side) and a whole-lung segmentation approach were compared.In both approaches PBF and PBV were significantly reduced on the ipsilateral side (p always < 0.0001). In ipsilateral lungs, PBF of the ROI-based and the whole-lung segmentation-based approach was equal (p=0.50). In contralateral lungs, the ROI-based approach significantly overestimated PBF in comparison to the whole-lung segmentation approach by approximately 9.5 % (p=0.0013).MR lung perfusion in 2-year-old children after CDH is significantly reduced ipsilaterally. In the contralateral lung, the ROI-based approach significantly overestimates perfusion, which can be explained by exclusion of the most ventral parts of the lung. Therefore whole-lung segmentation should be preferred.aEuro cent Ipsilaterally, absolute lung perfusion after CDH is reduced in whole-lung analysis.aEuro cent Ipsilaterally, the ROI- and whole-lung-based approaches generate identical results.aEuro cent Contralaterally, the ROI-based approach significantly overestimates perfusion results.aEuro cent Whole lung should be analysed in MR lung perfusion imaging.aEuro cent MR lung perfusion measurement is a radiation-free parameter of lung function.