Local recurrence after amputation for osteosarcoma.
Local recurrence after amputation for osteosarcoma.
复制标题
骨肉瘤截肢后局部复发。
DOI：
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发表时间：
1980
影响因子：
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通讯作者：
M. Laus
中科院分区：
文献类型：
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作者：
M. Campanacci;M. Laus
248例高级别中央型骨肉瘤采用截肢或关节离断术治疗，5.2%的肿瘤在截肢部位复发。以下原因可能是导致局部复发的原因：截肢的平面离肿瘤太近；肿瘤有未被识别的髓内延伸；在以前的块切除中，肿瘤细胞可能已经种植在软组织中；原发肿瘤太广泛，甚至不能进行根治性手术；可能存在跳跃转移；医源性肿瘤植入可能发生在截肢过程中进行活组织检查时。原发性骨肉瘤的治疗应该考虑到所有这些可能性。在我们的经验中，辅助化疗并没有显著改变局部复发的频率，应该通过根治性手术治疗，如果不可能，则通过放射治疗；化疗可以用作辅助治疗。局部复发预后较差。
Two hundred and forty-eight high-grade central osteosarcomata were treated by amputation or disarticulation; in 5.2 per cent the tumour recurred at the amputation site. The following causes may be responsible for local recurrence: the level of the amputation is too close to the tumour; there is an unrecognised intramedullary extension of the tumour; during a previous block resection tumour cells may have been seeded in the soft tissues; the primary tumour was too extensive even for radical surgery; "skip" metastases may have been present; iatrogenic tumour implantation may have occurred while a biopsy was being performed during the course of an amputation. Treatment of the primary osteosarcoma should take all these possibilities into account. In our experience adjuvant chemotherapy has not significantly changed the frequency of local recurrences which should be treated by radical operation or, if this is not possible, by irradiation; chemotherapy may be used as an adjuvant. The prognosis of local recurrences is bad.