Fungicidal activity of cellobiose lipids from culture broth of yeast Cryptococcus humicola and Pseudozyma fusiformata
Fungicidal activity of cellobiose lipids from culture broth of yeast Cryptococcus humicola and Pseudozyma fusiformata
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腐殖隐球菌和梭形假酵母培养液中纤维二糖脂质的杀菌活性
DOI：
10.1134/s1068162007010189
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发表时间：
2007
影响因子：
1
通讯作者：
N. Nifantiev
中科院分区：
文献类型：
--
作者：
E. Kulakovskaya;T. Kulakovskaya;V. I. Golubev;A. Shashkov;A. Grachev;N. Nifantiev
酵母菌隐球菌和梭形假酵母的纤维二糖脂对不同的酵母菌具有相似的杀菌活性，包括致病性隐球菌和酵母菌。担子菌酵母对这些制剂表现出最大的敏感性;例如，在浓度为0.02 mg/ml的糖脂溶液中孵育30分钟后，新型隐球菌Filobasidiella neoformansalmost细胞完全死亡。对子囊菌酵母，包括致病性酵母菌，只有在糖脂浓度高5至8倍时才能达到同样的效果。从P. fusiformata，与Cr.腐质霉中纤维二糖的O-取代基为羟基己酸，糖苷配基中增加了15-羟基，其抑制菌丝体真菌生长的效果优于腐质霉中纤维二糖脂。腐质霉
Cellobiose lipids of yeast fungiCryptococcus huminolaandPseudozyma fusiformatahave similar fungicidal activities against different yeast, including pathogenicCryptococcusandCandidaspecies. Basidiomycetic yeast reveals maximum sensitivity to these preparations; e.g., cells of cryptococcusFilobasidiella neoformansalmost completely die after 30-min incubation in a glycolipid solution at a concentration of 0.02 mg/ml. The same effect toward ascomycetous yeast, including pathogenicCandidaspecies, is achieved only at five to eight times higher concentrations of glycolipids. The cellobiose lipid fromP. fusiformata, which, unlike glycolipid fromCr. humicola, has hydroxycaproic acid residue asO-subtituent of cellobiose and additional 15-hydroxy group in aglycone, inhibits the growth of the studied mycelial fungi more efficiently than the cellobiose lipid fromCr. humicola.