Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians
Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians
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DOI：
10.1210/jc.86.11.5366
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发表时间：
2001-11-01
影响因子：
5.8
通讯作者：
Simonson, DC
中科院分区：
文献类型：
--
作者：
Raji, A;Seely, EW;Simonson, DC
先前的研究表明，与高加索人相比，亚洲印度人（Als）具有胰岛素抵抗性，患糖尿病和冠心病的风险很高。为了研究体脂分布的差异是否导致这种风险，12名年龄和体重指数（BMI）匹配的健康白种人和12名白种人接受了75克口服葡萄糖耐量试验、2小时正糖高胰岛素钳夹、腹部（L2-3）计算机断层扫描和空腹脂质和纤溶酶原激活物抑制剂-1 （PAI-1）水平。尽管空腹血糖水平相似，但在口服糖耐量试验中，AIs患者表现出空腹高胰岛素血症（P = 0.001），较高的葡萄糖（P = 0.03）和胰岛素（P = 0.004）水平，葡萄糖处置率（R-d）降低（4.7 +/- 0.4）。7.5 +/- 0.3 mg/kg / min, P < 0.0001)。AIs患者高密度脂蛋白显著降低，低密度脂蛋白显著升高，PAI-1水平显著升高（P = 0.01）。尽管BMI相似，但Als的总腹部脂肪（P = 0.04）和内脏脂肪（P = 0.04）明显更高。在所有受试者中，脂肪量测量与夹持期间的Rd呈负相关（r = -0.47至-0.61,P < 0.01-0.001）。内脏脂肪量与甘油三酯、低密度脂蛋白和高密度脂蛋白相关（P < 0.002-0.0001）。白种人PAI-1与Rd呈负相关（r = -0.70, P < 0.01），白种人PAI-1与Rd无相关（r = -0.24, P = 0.44）。对于可比的BMI和年龄，与白种人相比，健康的ai具有胰岛素抵抗、血脂异常和心血管风险增加的生理指标。体内脂肪分布的改变——尤其是内脏脂肪的增加——可能导致这些异常。
Previous studies have shown that Asian Indians (Als) are insulin resistant and at high risk for developing diabetes and coronary heart disease, compared with Caucasians. To examine whether differences in body fat distribution contribute to this risk, 12 healthy Als and 12 Caucasians matched for age and body mass index (BMI) underwent a 75-g oral glucose tolerance test, 2-h euglycemic hyperinsulinemic clamp, abdominal (L2-3) computed tomography scan, and fasting lipid and plasminogen activator inhibitor-1 (PAI-1) levels. Despite similar fasting plasma glucose levels, AIs exhibited fasting hyperinsulinemia (P = 0.001), higher glucose (P = 0.03) and insulin (P = 0.004) levels during the oral glucose tolerance test, and reduced glucose disposal rate (R-d) (4.7 +/- 0.4 as. 7.5 +/- 0.3 mg/kg per min, P < 0.0001) during the clamp. AIs had significantly lower high-density lipoprotein, higher low-density lipoprotein, and significantly higher PAI-1 levels (P = 0.01). Despite similar BMI, Als had significantly greater total abdominal fat (P = 0.04) and visceral fat (P = 0.04). In all subjects, measures of fat mass were inversely correlated with Rd during the clamp (r = -0.47 to -0.61, P < 0.01-0.001). Visceral fat mass was correlated with triglycerides, low-density lipoprotein, and high-density lipoprotein (P < 0.002-0.0001). PAI-1 was inversely correlated with Rd in Als (r = -0.70, P < 0.01) and not in Caucasians (r = -0.24, P = 0.44). For comparable BMI and age, healthy AIs have physiologic markers for insulin resistance, dyslipidemia, and increased cardiovascular risk, compared with Caucasians. Alterations in body fat distribution-particularly increased visceral fat-may contribute to these abnormalities.