From azides to nitriles.: A novel fast transformation made possible by BrF3
From azides to nitriles.: A novel fast transformation made possible by BrF3
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DOI：
10.1021/ol050523h
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发表时间：
2005-05-26
期刊：
影响因子：
5.2
通讯作者：
Rozen, S
中科院分区：
文献类型：
--
作者：
Sasson, R;Rozen, S
各种烷基和芳基叠氮化物，容易从卤化物或醇，转化成相应的腈使用三氟化溴在中等到良好的产率。该反应是一般性的，并给出了积极的结果与脂肪族，芳香族，环状和官能化的叠氮化物。它也可以应用于光学活性腈的合成。
Various alkyl and aryl azides, readily obtained from halides or alcohols, were transformed into the corresponding nitriles using bromine trifluoride in moderate to good yields. The reaction is general and gives positive results with aliphatic, aromatic, cyclic, and functionalized azides. It can also be applied to the synthesis of optically active nitriles.