REGIONAL PULMONARY FUNCTION STUDIED WITH XENON133
REGIONAL PULMONARY FUNCTION STUDIED WITH XENON133
复制标题
DOI：
10.1172/jci104505
复制
发表时间：
1962-01-01
影响因子：
15.9
通讯作者：
BATES, DV
中科院分区：
文献类型：
--
作者：
BALL, WC;NEWSHAM, LGS;BATES, DV
肺内的化学惰性放射性气体通过外部放置的闪烁计数器检测。肺的6个不同区域的相对通气和灌注的指数是从单次呼吸空气混合物后、再呼吸混合物后和静脉注射溶解的Xe 133后的外部计数率计算的。这些指标与计数视野内的肺体积无关。在21名正常受试者中的发现表明：（a）肺下部比肺上部稍大的通气和大得多的灌注;（B）深吸气时比安静呼吸时稍均匀的吸入空气分布;（c）左肺中部和下部比右肺的通气更大;和d）右肺下部的灌注大于左肺下部的灌注。40例各种心脏或肺部疾病的患者进行了研究，并提出了4个说明性的情况下。将该方法与West及其同事的O 15技术（J. Clin. Invest. 40：1，1961）。
A chemically inert radioactive gas within the lung is detected by means of externally placed scintillation counters. Indices of relative ventilation and perfusion for 6 different regions of the lung are calculated from external counting rates after a single breath of air-Xe mixture, after rebreathing the mixture, and after intravenous injection of dissolved Xe133. These indices are independent of the volume of lung within the counting field. Findings in 21 seated normal subjects indicate a) somewhat greater ventilation and much greater perfusion in the lower than in the upper portion of the lung; b) slightly more uniform inspired air distribution on deep inspiration than during quite breathing; c) greater ventilation of the middle and lower portions of the lung on the left than on the right; and d) greater perfusion of the lower portion of the lung on the right than on the left. Forty patients with various cardiac or pulmonary disorders have been studied, and 4 illustrative cases are presented. The method is compared with the O15 technique of West and co-workers (J. Clin. Invest. 40:1, 1961).