The pathology of devil facial tumor disease (DFTD) in Tasmanian devils (Sarcophilus harrisii)
The pathology of devil facial tumor disease (DFTD) in Tasmanian devils (Sarcophilus harrisii)
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DOI：
10.1354/vp.43-6-890
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发表时间：
2006-11-01
影响因子：
2.4
通讯作者：
Sharpe, R.
中科院分区：
文献类型：
--
作者：
Loh, R.;Bergfeld, J.;Sharpe, R.
在野生塔斯马尼亚魔鬼（Sarcophilus harrisii）中发现了一种被称为魔鬼面部肿瘤病（DFTD）的毁容和衰弱的肿瘤疾病，占其自然分布区的51%，在某些地区人口下降高达80%（C。霍金斯，个人通信）。在2001年至2004年期间，共审查了91起案件。肿瘤表现为大的、实性的软组织肿块，通常表面扁平，中心溃疡，渗出。它们通常是多中心的，首先出现在口腔，面部或颈部区域。在组织学上，肿瘤由圆形至梭形细胞的局限性至浸润性结节聚集体组成，通常在假包膜内，并被精细的纤维隔膜分成小叶。65%的病例具有局部侵袭性和转移性。在光镜和电镜检查下，肿瘤细胞群中的细胞学分化最小。结果表明DFTD是一种未分化的软组织肿瘤。
A disfiguring and debilitating neoplastic condition known as devil facial tumor disease (DFTD) has been discovered in wild Tasmanian Devils (Sarcophilus harrisii) across 51% of its natural range, with population declines of up to 80% in some areas (C. Hawkins, personal communication). Between 2001 and 2004, 91 cases were examined. The tumors presented as large, solid, soft tissue masses usually with flattened, centrally ulcerated, and exudative surfaces. They were typically multicentric, appearing first in the oral, face, or neck regions. Histologically, the tumors were composed of circumscribed to infiltrative nodular aggregates of round to spindle-shaped cells, often within a pseudocapsule and divided into lobules by delicate fibrous septae. They were locally aggressive and metastasized in 65% of cases. There was minimal cytologic differentiation among the tumor cell population under light and electron microscopic examination. The results indicate DFTD to be an undifferentiated soft tissue neoplasm.