Inhibition of collagen synthesis as a treatment for paraquat poisoning.
Inhibition of collagen synthesis as a treatment for paraquat poisoning.
复制标题
抑制胶原蛋白合成作为百草枯中毒的治疗方法。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
F. Oehme
中科院分区：
文献类型：
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作者：
F. Akahori;F. Oehme
观察了L-3，4-脱氢脯氨酸(L-DHP)和DL-3，4-脱氢脯氨酸(DL-DHP)对百草枯诱导的雄性大鼠肺纤维化的影响。大鼠皮下注射7.0 mg/kg体重的百草枯7d或8d后10d体重下降。L-DHP或DL-DHP(25 mg/kg)皮下注射，第11~24天每日1次。百草枯处理组大鼠肺组织胶原含量明显升高。除死于急性或亚慢性百草枯中毒的大鼠(至第16天)外，在本研究的100天内，其他大鼠未见百草枯所致的致命性肺纤维化。L和DL-DHP对肺胶原合成的抑制作用差异无统计学意义。
The effect of L-3, 4-dehydroproline (L-DHP) or DL-3, 4-dehydroproline (DL-DHP) on paraquat-induced pulmonary fibrosis was examined in male rats. Rats that declined in body weight during the 10 days after receiving 7.0 mg paraquat dichloride/kg body weight sc for 7 or 8 days were used. L-DHP or DL-DHP (25 mg/kg) was administered sc daily on days 11 through 24. The lung collagen of animals treated with paraquat was significantly elevated. Except for rats that died from acute or subchronic paraquat toxicity (till day 16), paraquat-induced fatal pulmonary fibrosis was not seen in other rats during the 100 days of this study. The effect of L-DHP or DL-DHP on inhibiting lung collagen synthesis was not statistically significant.