Biomedical Informatics on the Cloud: A Treasure Hunt for Advancing Cardiovascular Medicine.
Biomedical Informatics on the Cloud: A Treasure Hunt for Advancing Cardiovascular Medicine.
复制标题
云上的生物医学信息学：一种用于推进心血管医学的寻宝活动。
DOI：
10.1161/circresaha.117.310967
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发表时间：
2018-04-27
影响因子：
20.1
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Ping P;Hermjakob H;Polson JS;Benos PV;Wang W
在心血管医学的数字化时代，生物医学发现的速度可以通过挖掘潜在知识集合所需的指导和资源来大大加快。一个统一的计算平台利用元数据，不仅提供方向，而且使研究人员能够挖掘丰富的生物医学信息，并形成新的机制见解。这篇综述借此机会概述了基于云的计算环境，包括元数据的功能角色，索引和搜索的架构模式，以及机器学习支持的分子签名提取的实际场景。通过介绍几个已建立的资源和最先进的工作流程，我们与读者分享了一个广泛定义的信息学框架，以表型心血管健康和疾病。
In the digital age of cardiovascular medicine, the rate of biomedical discovery can be greatly accelerated by the guidance and resources required to unearth potential collections of knowledge. A unified computational platform leverages metadata to not only provide direction but also empower researchers to mine a wealth of biomedical information and forge novel mechanistic insights. This review takes the opportunity to present an overview of the cloud-based computational environment, including the functional roles of metadata, the architecture schema of indexing and search, and the practical scenarios of machine learning-supported molecular signature extraction. By introducing several established resources and state-of-the-art workflows, we share with our readers a broadly-defined informatics framework to phenotype cardiovascular health and disease.