Longitudinal association of hypertension and diabetes mellitus with cognitive functioning in a general 70-year-old population: the SONIC study
Longitudinal association of hypertension and diabetes mellitus with cognitive functioning in a general 70-year-old population: the SONIC study
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DOI：
10.1038/hr.2017.15
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发表时间：
2017-02
影响因子：
5.4
通讯作者：
Hirochika Ryuno;K. Kamide;Y. Gondo;M. Kabayama;R. Oguro;Chikako Nakama;Serina Yokoyama;Motonori Nagasawa;Satomi Maeda-Hirao;Yuki Imaizumi;M. Takeya;Hiroko Yamamoto;M. Takeda;Y. Takami;N. Itoh;Y. Takeya;Koichi Yamamoto;K. Sugimoto;Takeshi Nakagawa;S. Yasumoto;K. Ikebe;H. Inagaki;Y. Masui;M. Takayama;Y. Arai;T. Ishizaki;R. Takahashi;H. Rakugi
中科院分区：
文献类型：
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作者：
Hirochika Ryuno;K. Kamide;Y. Gondo;M. Kabayama;R. Oguro;Chikako Nakama;Serina Yokoyama;Motonori Nagasawa;Satomi Maeda-Hirao;Yuki Imaizumi;M. Takeya;Hiroko Yamamoto;M. Takeda;Y. Takami;N. Itoh;Y. Takeya;Koichi Yamamoto;K. Sugimoto;Takeshi Nakagawa;S. Yasumoto;K. Ikebe;H. Inagaki;Y. Masui;M. Takayama;Y. Arai;T. Ishizaki;R. Takahashi;H. Rakugi
中年人的高血压和糖尿病都被认为是认知能力下降的预测指标。然而，高血压、糖尿病及其组合与认知功能的关联在老年人中仍然存在争议。本研究的目的是基于 3 年纵向分析，调查 70 岁老年人认知能力下降与高血压、糖尿病及其组合之间的关联。从普通人群中随机招募参加日本七十多岁、八十多岁和九十多岁的百岁老人纵向队列研究（SONIC）的 454 名 70（±1）岁人士，并进行为期 3 年的监测。这些数据包括大部分人口统计数据、蒙特利尔认知评估日语版（MoCA-J）测量的认知功能、血压、血液化学和其他病史，是在基线和随访期间收集的。随访调查中发现的高血压患病率明显高于基线时的患病率。随访时的平均 MoCA-J 评分与基线时获得的评分没有显着差异。然而，患有糖尿病，尤其是基线时患有高血压的参与者，其 MoCA-J 评分显着低于没有生活方式相关疾病的参与者。考虑到基线调整后随访期间获得的 MoCA-J 评分，相对于性别、体重指数、血脂异常、吸烟、过量饮酒、降压治疗和教育水平，高血压和糖尿病的组合仍然是认知能力下降的重要危险因素（β=− 0.14；P < 0.01）。我们的研究结果表明，糖尿病以及高血压和糖尿病的组合是 70 岁老年人未来认知能力下降的明显危险因素。
Both hypertension and diabetes in middle-aged individuals have been suggested to be predictive indicators of cognitive decline. However, the association of hypertension, diabetes and their combination with cognitive functioning is still controversial in older people. The purpose of this study was to investigate the association between cognitive decline and hypertension, diabetes, and their combination in 70-year-old people based on a 3-year longitudinal analysis. Four hundred and fifty-four people aged 70 (±1) years who participated in the Japanese longitudinal cohort study of Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) were recruited randomly from a general population and were monitored for 3 years. The data, including most of the demographics, cognitive functioning measured by the Montreal Cognitive Assessment Japanese version (MoCA-J), blood pressure, blood chemistry and other medical histories, were collected at baseline and during the follow-up. The prevalence of hypertension noted in the follow-up survey was significantly higher than than noted at baseline. The mean MoCA-J score at follow-up was not significantly different from the score obtained at baseline. However, the participants with diabetes, especially combined with hypertension at baseline, had significantly lower MoCA-J scores than those without lifestyle-related diseases. The combination of hypertension and diabetes was still a significant risk factor for cognitive decline, considering the MoCA-J scores obtained during the follow-up after adjustments at baseline, relative to sex, body mass index, dyslipidemia, smoking, excessive alcohol intake, antihypertensive treatment and education level (β=− 0.14; P< 0.01). Our findings indicate that diabetes and the combination of hypertension and diabetes are clear risk factors for future cognitive decline in elderly individuals who are 70 years of age.