Aβ42 and Aβ40: similarities and differences
Aβ42 and Aβ40: similarities and differences
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A beta 42 和 A beta 40：相似点和不同点
DOI：
10.1002/psc.2789
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发表时间：
2015-07-01
影响因子：
2.1
通讯作者：
Li, Yan-Mei
中科院分区：
文献类型：
--
作者：
Qiu, Tian;Liu, Qian;Li, Yan-Mei
淀粉样蛋白（A）肽在大脑中的异常积累是阿尔茨海默病最重要的标志之一。A是一种具有39-43个残基的聚集倾向和毒性多肽，来源于淀粉样前体蛋白的蛋白水解过程。根据淀粉样蛋白假说，大脑中A的异常积累是驱动阿尔茨海默病病理的主要影响。在各种A亚型中，A40和A42被认为是最重要的亚型。虽然这两种A仅在两个氨基酸残基上不同，但最近的研究表明，它们在代谢、生理功能、毒性和聚集机制方面存在显着差异。本文主要综述了A42和A40的异同，并对A42的选择性抑制剂和探针的研究进展进行了介绍。版权所有（c）2015 European Peptide Society and John Wiley & Sons，Ltd.
The abnormal accumulation of amyloid- (A) peptide in the brain is one of the most important hallmarks of Alzheimer's disease. A is an aggregation-prone and toxic polypeptide with 39-43 residues, derived from the amyloid precursor protein proteolysis process. According to the amyloid hypothesis, abnormal accumulation of A in the brain is the primary influence driving Alzheimer's disease pathologies. Among all kinds of A isoforms, A40 and A42 are believed to be the most important ones. Although these two kinds of A differ only in two amino acid residues, recent studies show that they differ significantly in their metabolism, physiological functions, toxicities, and aggregation mechanism. In this review, we mainly summarize the similarities and differences between A42 and A40, recent studies on selective inhibitors as well as probes will also be mentioned. Copyright (c) 2015 European Peptide Society and John Wiley & Sons, Ltd.