Long-term health-related quality of life following surgery for oesophageal cancer
Long-term health-related quality of life following surgery for oesophageal cancer
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DOI：
10.1002/bjs.6293
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发表时间：
2008-09-01
影响因子：
9.6
通讯作者：
Lagergren, P.
中科院分区：
文献类型：
--
作者：
Djarv, T.;Lagergren, J.;Lagergren, P.
背景：本研究的目的是评估手术治愈食管癌患者的健康相关生活质量（HRQL）。方法：对2001年4月至2004年1月期间瑞典全国范围内接受食管癌切除术的患者进行前瞻性研究，并与瑞典年龄和性别调整后的参考人群进行比较。经验证的欧洲癌症研究和治疗组织生活质量问卷用于评估手术后6个月和3年的HRQL。组间平均得分相差10分或10分以上被认为具有临床相关性，并进一步检验有无统计学意义。结果：358例患者中，117例（32.7%）存活3年以上。其中，87名患者（74.4%）回答了问卷调查。术后6个月，HRQL的大多数方面明显差于参考人群，3年时没有改善。与参考人群相比，存活3年的患者报告的角色和社会功能明显较差，疲劳、腹泻、食欲不振、恶心和呕吐等问题明显更多。结论：食管切除术后长期幸存者的HRQL在术后6个月至3年内没有改善，并且比可比参考人群的HRQL更差。
Background: The aim of the study was to assess health-related quality of life (HRQL) in patients with surgically cured oesophageal cancer. Methods: A Swedish nationwide cohort of patients undergoing oesophagectomy for cancer between April 2001 and January 2004 was studied prospectively, and compared with a Swedish age- and sex-adjusted reference population. Validated European Organisation for Research and Treatment of Cancer quality of life questionnaires were used to assess HRQL at 6 months and 3 years after surgery. A mean score difference of 10 or more between groups was considered clinically relevant and tested further for statistical significance. Results: Of 358 patients, 117 (32.7 per cent) survived for at least 3 years. Of these, 87 patients (74.4 per cent) responded to the questionnaires. Six months after surgery, most aspects of HRQL were substantially worse than in the reference population with no improvement at 3 years. Patients alive at 3 years reported significantly poorer role and social function, and significantly more problems with fatigue, diarrhoea, appetite loss, nausea and vomiting, than in the reference population. Conclusion: HRQL in long-term survivors after oesophagectomy does not improve between 6 months and 3 years after surgery, and is worse than that in a comparable reference population.