Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity.
Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity.
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DOI：
10.1111/ejn.12191
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Setlow B
中科院分区：
文献类型：
--
作者：
Simon NW;Beas BS;Montgomery KS;Haberman RP;Bizon JL;Setlow B
多巴胺受体水平的变化与冲动性的不同方面有关。为了进一步描绘冲动行为（无法抑制优势运动反应）和冲动选择（延迟厌恶）背后的神经基础，我们用低频率反应差别强化任务和延迟折扣任务对大鼠进行了特征描述。我们还测量了基于努力的折扣任务中的表现。然后，我们利用原位杂交技术评估了前额叶皮质和伏隔核各亚区的D1和D2多巴胺受体mRNA表达，并将这些数据与行为表现进行了比较。不同脑区的D1和D2受体mRNA表达可预测冲动行为。在伏隔核内，各亚区和受体亚型之间存在分离；壳核中较高的D1 mRNA表达预示着更强的冲动行为，而核心区较低的D2 mRNA表达预示着更强的冲动行为。我们还观察到前边缘皮质中冲动行为与D2 mRNA表达呈负相关。有趣的是，尽管冲动行为和冲动选择的行为指标不相关，但在前边缘皮质中，冲动选择和D2 mRNA之间存在类似的关系。最后，我们发现岛叶皮质中较高的D1 mRNA表达和边缘下皮质中较低的D2 mRNA表达都与为获取奖励而付出努力的意愿有关。值得注意的是，这些区域的多巴胺受体mRNA与冲动性的任何一个方面都无关。这里呈现的数据为不同形式的冲动性以及基于努力的决策提供了新的分子和神经解剖学上的区别。
Variation in dopamine receptor levels has been associated with different facets of impulsivity. To further delineate the neural substrates underlying impulsive action (inability to withhold a prepotent motor response) and impulsive choice (delay aversion), we characterised rats in the Differential Reinforcement of Low Rates of Responding task and a delay discounting task. We also measured performance on an effort-based discounting task. We then assessed D1 and D2 dopamine receptor mRNA expression in subregions of the prefrontal cortex and nucleus accumbens using in situ hybridisation, and compared these data with behavioral performance. Expression of D1 and D2 receptor mRNA in distinct brain regions was predictive of impulsive action. A dissociation within the nucleus accumbens was observed between subregions and receptor subtypes; higher D1 mRNA expression in the shell predicted greater impulsive action, whereas lower D2 mRNA expression in the core predicted greater impulsive action. We also observed a negative correlation between impulsive action and D2 mRNA expression in the prelimbic cortex. Interestingly, a similar relationship was present between impulsive choice and prelimbic cortex D2 mRNA, despite the fact that behavioral indices of impulsive action and impulsive choice were uncorrelated. Finally, we found that both high D1 mRNA expression in the insular cortex and low D2 mRNA expression in the infralimbic cortex were associated with willingness to exert effort for rewards. Notably, dopamine receptor mRNA in these regions was not associated with either facet of impulsivity. The data presented here provide novel molecular and neuroanatomical distinctions between different forms of impulsivity, as well as effort-based decision-making.
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