Effects of common environmental endocrine-disrupting chemicals on zebrafish behavior
Effects of common environmental endocrine-disrupting chemicals on zebrafish behavior
复制标题
常见环境内分泌干扰化学物质对斑马鱼行为的影响
DOI：
10.1016/j.watres.2021.117826
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发表时间：
2022
期刊：
影响因子：
12.8
通讯作者：
Ying Zhang
中科院分区：
文献类型：
--
作者：
Yue Tao;Zixu Li;Yang Yang;Yaqi Jiao;Jianhua Qu;Yifan Wang;Ying Zhang
环境内分泌干扰物（Environmental endocrine-disrupting chemicals, EDCs）是一种外源性有机污染物，在自然水体环境中普遍存在。因此，本文主要以斑马鱼为研究对象，探讨不同EDCs对斑马鱼行为的影响，以及驱动这些影响的分子机制。此外，本研究总结了目前关于不同EDCs在斑马鱼中的神经调节作用的知识。本研究还综述了斑马鱼行为研究的现状，以及在分子水平上单一和混合污染物驱动行为失调的潜在机制，以及斑马鱼行为实验在神经科学研究中的应用。这一综述拓宽了我们对EDCs对斑马鱼行为影响的认识，并为今后的研究提供了指导。
Environmental endocrine-disrupting chemicals (EDCs), a type of exogenous organic pollutants, are ubiquitous in natural aquatic environments. Therefor, this review focused on the use of the zebrafish as a model to explore the effect of different EDCs on behavior, as well as the molecular mechanisms that drive these effects. Furthermore, our study summarizes the current knowledge on the neuromodulatory effects of different EDCs in zebrafish. This study also reviews the current state of zebrafish behavior research, in addition to the potential mechanisms of single and mixed pollutant-driven behavioral dysregulation at the molecular level, as well as the applications of zebrafish behavior experiments for neuroscience research. This review broadens our understanding of the influence of EDCs on zebrafish behavior and provides guidance for future research.