Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
复制标题
安非他明、甲基安非他明、麻黄碱、芬美嗪和哌醋甲酯对人体的生理、主观和行为影响
DOI：
--
复制
发表时间：
1971
期刊：
影响因子：
--
通讯作者：
D. Jasinski
中科院分区：
文献类型：
--
作者：
W. Martin;J. Sloan;J. Sapira;D. Jasinski
在人体内研究了五种中枢作用的交感神经刺激胺，即D-苯丙胺、D-甲基苯丙胺、麻黄碱、苯美曲津和哌醋甲酯。所有这些药物都会增加血压和呼吸频率，产生类似类型的次要变化，并增加肾上腺素的排泄。关于这些参数，对其相对效力的估计之间有很高的一致性。对不同参数的效力估计之间的一致性表明，但并不能证明，这五种药物共享共同的中枢作用模式。此外，如果动物研究阐明的外周活动模式对人类是正确的，这项研究表明，它们在人类体内的中枢活动不太可能是大脑中去甲肾上腺素释放的结果。
Five centrally acting sympathomimetic amines, d‐amphetamine, d‐methamphetamine, ephedrine, phenmetrazine, and methylphenidate, were studied in man. All of these agents increased blood pressure and respiratory rate, produced similar types of subiective changes, and increased the excretion of epinephrine. With regard to these parameters, there was a high concordance between estimates of their relative potencies. The concordance between the potency estimates for the different parameters suggests, but does not prove, that these five agents share a common mode of central action. Further, if the peripheral modes of action as elucidated by animal studies are true for man, this study suggests that it is unlikely that their central actions in man are a consequence of the release of norepinephrine in the brain.