Iron status indicators in women with prior neural tube defect-affected pregnancies
Iron status indicators in women with prior neural tube defect-affected pregnancies
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DOI：
10.1007/s10995-005-0017-3
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发表时间：
2005-12-01
影响因子：
2.3
通讯作者：
Hendricks, K
中科院分区：
文献类型：
--
作者：
Felkner, MM;Suarez, L;Hendricks, K
目的：缺铁是孕妇最常见的营养缺乏症，与胎儿的不良影响有关。我们描述了在墨西哥裔美国高危人群中，各种铁缺乏指数与神经管缺陷(NTD)风险的关系。方法：研究对象为1995-2000年间德克萨斯州-墨西哥边境14个县的158名病例妇女(受NTD影响的孕妇)和189名对照妇女(正常分娩)。面谈和实验室分析提供了数据。结果：与对照组相比，病例组妇女铁储备(血清铁蛋白和铁蛋白含量为30 mg/L)较高(OR=1.8，95%CI=1.0~3.3)。这种风险效应不能用低叶酸、B-12或其他危险因素来解释。结论：低血清铁蛋白可能反映了多种长期因素的叠加作用，其中许多因素与贫困有关，如饮食质量差、缺乏补充剂、频繁怀孕等。在这一人群中，需要进行产期护理。
Objectives: Iron deficiency is the most common nutrient deficiency in pregnant women and has been linked to negative impacts on the fetus. We describe the association of various iron-deficiency indices with risk of neural tube defect (NTD) among a high-risk Mexican-American population. Methods: The study included 158 case-women (NTD-affected pregnancies) and 189 control-women (normal births) who were residents of the 14 Texas-Mexico border counties and delivered or terminated pregnancies during 1995-2000. In-person interviews and laboratory assays provided data. Results: Case-women had higher odds of having minimal or no iron stores (serum ferritin < 30 mu g/L) compared to control-women (OR = 1.8, 95% CI = 1.0-3.3). The risk effect was not explained by low folate or B-12 or other risk factors. Conclusion: Low serum ferritin may reflect the additive effect of multiple long-term factors, many of them related to poverty such as poor quality diet, lack of supplementation, and frequent pregnancies. Interpartum care is indicated in this population.