Dysregulation of the fibroblast growth factor system in major depression
Dysregulation of the fibroblast growth factor system in major depression
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DOI：
10.1073/pnas.0406788101
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发表时间：
2004-10-26
影响因子：
11.1
通讯作者：
Akil, H
中科院分区：
文献类型：
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作者：
Evans, SJ;Choudary, PV;Akil, H
在这篇报告中，我们描述了在患有重度抑郁症（MDD）的人类受试者的大脑额叶皮质区域中几种成纤维细胞生长因子（FGF）系统转录物的失调。这种基因表达的改变是通过对重度抑郁症、双相情感障碍和非精神病对照受试者额叶皮质组织的微阵列分析发现的，并通过实时定量PCR分析得到了验证，重要的是，在重度抑郁症受试者的单独队列中得到了验证。此外，我们通过对特定5 -羟色胺再摄取抑制剂（SSRI）治疗和非SSRI治疗的MDD受试者的单独分析表明，观察到的FGF转录物表达的变化并非继发于药物治疗。相反，特定FGF转录物的变化被SSRIs减弱，因此可能部分负责这些药物的作用机制。我们还提供了在这些死后样本中检测到的所有其他生长因子和生长因子受体的基因表达谱。
In this report we describe findings that imply dysregulation of several fibroblast growth factor (FGF) system transcripts in frontal cortical regions of brains from human subjects with major depressive disorder (MDD). This altered gene expression was discovered by microarray analysis of frontal cortical tissue from MDD, bipolar, and nonpsychiatric control subjects and was verified by quantitative real-time PCR analysis and, importantly, in a separate cohort of MDD subjects. Furthermore, we show, through a separate analysis of specific serotonin reuptake inhibitor (SSRI)-treated and non-SSRI-treated MDD subjects that the observed changes in expression of FGF transcripts are not secondary to drug treatment. Rather, changes in specific FGF transcripts are attenuated by SSRIs and may thus be partially responsible for the mechanism of action of these drugs. We also make available the gene-expression profile of all of the other growth factors and growth factor receptors detected in these postmortem samples.