Material Properties of Nonpregnant and Pregnant Human Uterine Layers.
Material Properties of Nonpregnant and Pregnant Human Uterine Layers.
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非怀孕和怀孕人类子宫层的材料特性。
DOI：
10.1101/2023.08.07.551726
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Myers,KristinM
中科院分区：
文献类型：
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作者：
Fodera,DaniellaM;Russell,SerenaR;Lund-Jackson,JohannaL;Fang,Shuyang;Chen,Xiaowei;Vink,Joy-SarahY;Oyen,MichelleL;Myers,KristinM
子宫在妊娠期具有重要的生物力学功能，从着床到分娩，子宫经历了戏剧性的物质生长和重塑。人类子宫的内在物质特性以及它们在怀孕期间如何演变，人们知之甚少。为了解决这一知识缺口，并评估这些组织的异质性，所有人类子宫层的时间依赖性材料特性进行了测量与纳米压痕。子宫内膜-蜕膜层被认为是非妊娠和妊娠晚期组织中人类子宫的最不坚硬、最粘稠和最不渗透的层。妊娠期，子宫内膜-蜕膜变得更硬，粘性降低，而子宫肌层或子宫周膜中未观察到材料性质变化。此外，子宫材料的性质并没有显着差异之间的第三个三月妊娠组织与无胎盘植入。本研究所产生的基础数据将促进人类子宫生理学准确模型的发展，以研究妇科和产科疾病。
The uterus has critical biomechanical functions in pregnancy and undergoes dramatic material growth and remodeling from implantation to parturition. The intrinsic material properties of the human uterus and how they evolve in pregnancy are poorly understood. To address this knowledge gap and assess the heterogeneity of these tissues, the time-dependent material properties of all human uterine layers were measured with nanoindentation. The endometrium-decidua layer was found to be the least stiff, most viscous, and least permeable layer of the human uterus in nonpregnant and third-trimester pregnant tissues. In pregnancy, the endometrium-decidua becomes stiffer and less viscous with no material property changes observed in the myometrium or perimetrium. Additionally, uterine material properties did not significantly differ between third-trimester pregnant tissues with and without placenta accreta. The foundational data generated by this study will facilitate the development of physiologically accurate models of the human uterus to investigate gynecologic and obstetric disorders.