Anterior perirectal fat tissue thickness is a strong predictor of recurrence after high-intensity focused ultrasound for prostate cancer
Anterior perirectal fat tissue thickness is a strong predictor of recurrence after high-intensity focused ultrasound for prostate cancer
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DOI：
10.1111/j.1442-2042.2010.02585.x
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发表时间：
2010-09-01
影响因子：
2.6
通讯作者：
Asano, Tomohiko
中科院分区：
文献类型：
--
作者：
Sumitomo, Makoto;Asakuma, Junichi;Asano, Tomohiko
目的：探讨肥胖是否影响高强度聚焦超声（HIFU）治疗前列腺癌（CaP）的临床疗效。经直肠超声测量直肠前周脂肪组织（APFT）厚度。根据Phoenix定义，在生化失败、随访活检阳性或开始挽救治疗的情况下，认为治疗失败。考克斯比例风险分析用于确定无病生存期（DFS）的可能预测因子，并制作实验性脂肪组织模型以评估靶组织的消融效果。
Objective:To evaluate if and why obesity affects the clinical outcome in patients undergoing high-intensity focused ultrasound (HIFU) treatment for prostate cancer (CaP).Methods:115 patients who underwent HIFU treatment for localized CaP were categorized as obese, overweight or normal according to body mass index (BMI). The thickness of the anterior perirectal fat tissue (APFT) was measured by transrectal ultrasonography. Treatment was considered to have failed in the case of biochemical failure according to the Phoenix definition, positive follow-up biopsy or initiation of salvage therapy. Cox proportional hazards analyses were used to identify possible predictors for disease free survival (DFS), and an experimental fat tissue model was made to evaluate the ablation effect at the target tissue.Results: