Biomarkers of pesticide exposure and diabetes in the 1999-2004 National Health and Nutrition Examination Survey
Biomarkers of pesticide exposure and diabetes in the 1999-2004 National Health and Nutrition Examination Survey
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DOI：
10.1016/j.envint.2010.02.010
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发表时间：
2010-05-01
影响因子：
11.8
通讯作者：
Matheson, Eric M.
中科院分区：
文献类型：
--
作者：
Everett, Charles J.;Matheson, Eric M.
使用1999-2004年国家健康和营养检查调查（NHANES）评估了8种农药和农药代谢物与总糖尿病（诊断和未诊断）和糖尿病前期（糖化血红蛋白5.7-6.4%）的关系。在单独调整的logistic回归中，发现六种农药与总糖尿病相关。这些农药和农药代谢物是β-六氯环己烷、p，p '-DDE、p，p'-DDT、氯氧苄、反式-九氯和环氧化七氯。当检测升高的化合物数量时，6种化合物中4种或4种以上升高与未升高相比的比值比为4.99（95% CI 1.97-12.61）。当6种化合物一起测试在一个单一的组合调整逻辑回归只有氧氯噻嗪，代谢产物的氯，和七氯环氧化物，代谢产物的七氯，与总糖尿病显着相关。在联合校正的logistic回归中，调整后的氧氯噻嗪>= 14.5 ng/g脂质的比值比为1.90（95% CI 1.09-332），调整后的氧氯噻嗪= 14.6 ng/g脂质的比值比为1.70（95% CI 1.16-2.49），调整后的环氧七氯的比值比为1.70（95% CI 1.16-2.49）。
The associations of 8 pesticides and pesticide metabolites with total diabetes (diagnosed and undiagnosed) and pre-diabetes (glycohemoglobin 5.7-6.4%) were evaluated using the National Health and Nutrition Examination Survey (NHANES), 1999-2004. Six of the pesticides were found to be associated with total diabetes in separate adjusted logistic regressions. These pesticides and pesticide metabolites were beta-hexachlorocyclohexane, p,p'-DDE, p,p'-DDT, oxychlordane, trans-nonachlor, and heptachlor epoxide. When the number of compounds elevated was tested, 4 or more, of the 6, elevated had an odds ratio of 4.99 (95% CI 1.97-12.61) compared to none elevated. When the 6 compounds were tested together in a single combined adjusted logistic regression only oxychlordane, a metabolite of chlordane, and heptachlor epoxide, a metabolite of heptachlor, were significantly associated with total diabetes. In the combined adjusted logistic regression, oxychlordane >= 14.5 ng/g lipid adjusted had an odds ratios of 1.90 (95% CI 1.09-332) compared to oxychlordane = 14.6 ng/g lipid adjusted had an odds ratio of 1.70 (95% CI 1.16-2.49) compared to heptachlor epoxide