Mutation in Fas ligand impairs maturation of thymocytes bearing moderate affinity T cell receptors
Mutation in Fas ligand impairs maturation of thymocytes bearing moderate affinity T cell receptors
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DOI：
10.1084/jem.20030220
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发表时间：
2003-07-21
影响因子：
15.3
通讯作者：
Fink, PJ
中科院分区：
文献类型：
--
作者：
Boursalian, TE;Fink, PJ
Fas ligand, best known as a death-inducer, is also a costimulatory molecule required for maximal proliferation of mature antigen-specific CD4(+) and CD8(+) T cells. We now extend the role of Fas ligand by showing that it can also influence thymocyte development. T cell maturation in some, but not all, strains of TCR transgenic mice is severely impaired in thymocytes expressing mutant Fas ligand incapable of interacting with Fas. Mutant Fas ligand inhibits neither negative selection nor death by neglect. Instead, it appears to modulate positive selection of thymocytes expressing both class I- and class II-restricted T cell receptors of moderate affinity for their positively selecting ligands. Fas ligand is therefore an inducer of death, a costimulator of peripheral T cell activation, and an accessory molecule in positive selection.
