Exposure to ambient levels of particles emitted by traffic worsens emphysema in mice
Exposure to ambient levels of particles emitted by traffic worsens emphysema in mice
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DOI：
10.1016/j.envres.2009.03.002
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发表时间：
2009-07-01
影响因子：
8.3
通讯作者：
Martins, Milton A.
中科院分区：
文献类型：
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作者：
Lopes, Fernanda D. T. Q. S.;Pinto, Tatiana S.;Martins, Milton A.
目的：我们研究了慢性暴露（2个月）到周围水平的颗粒物（PM）对蛋白酶诱导的肺气肿和肺重塑小鼠的发展的影响。研究方法：Balb/c小鼠接受木瓜蛋白酶或生理盐水的滴鼻，并保持在位于高交通密度区域的两个暴露室中。其中一个接收环境空气，另一个具有PM过滤器。结果：过滤空气室和环境空气室的PM10平均浓度分别为2.68 ± 0.38和33.86 ± 2.09 μ g/m3（p
Objectives: We investigated effects of chronic exposure (2 months) to ambient levels of particulate matter (PM) on development of protease-induced emphysema and pulmonary remodeling in mice. Methods: Balb/c mice received nasal drop of either papain or normal saline and were kept in two exposure chambers situated in an area with high traffic density. One of them received ambient air and the other had filters for PM. Results: mean concentration of PM10 was 2.68 +/- 0.38 and 33.86 +/- 2.09 mu g/m(3), respectively, in the filtered and ambient air chambers (p