The Genetic Relationship Between Psychological Distress, Somatic Distress, Affective Disorders, and Substance Use in Young Australian Adults: A Multivariate Twin Study.
The Genetic Relationship Between Psychological Distress, Somatic Distress, Affective Disorders, and Substance Use in Young Australian Adults: A Multivariate Twin Study.
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澳大利亚年轻人的心理困扰、躯体困扰、情感障碍和药物使用之间的遗传关系：一项多变量双胞胎研究。
DOI：
10.1017/thg.2018.33
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Martin,NicholasG
中科院分区：
文献类型：
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作者：
Chang,Lun-Hsien;Couvy-Duchesne,Baptiste;Medland,SarahE;Gillespie,NathanA;Hickie,IanB;Parker,Richard;Martin,NicholasG
心理困扰（PSYCH），躯体困扰（索马），情感障碍（AD）和物质使用（SU）经常同时发生。然而，PSYCH和索马之间的遗传关系仍然研究不足。我们研究了遗传和环境的影响，这两种疾病和他们的共病AD和SU使用结构方程模型。使用12项问卷中的两个分量表，即躯体和心理健康报告，对1,548对双胞胎进行了自我报告的PSYCH和索马测量。它的可靠性和心理测量特性进行了检查。使用世界精神卫生复合国际诊断访谈和/或在线改编的1，663 - 2，132对双胞胎中获得了6个AD，涉及合法和非法物质，以及2个SU疾病。SU表型（遗传力：49-79%）被发现比情感障碍表型（遗传率：32-42%），索马（遗传率：25%）和PSYCH（遗传率：23%）更具遗传性。我们适合单独的非参数项目反应理论模型PSYCH，索马，AD和SU。IRT评分被用作拟合多变量遗传模型的精炼表型。最佳拟合模型显示PSYCH-AD（rG = 0.49）和SOMA-AD（rG =0.53）之间以及PSYCH-SU（rG = 0.23）和SOMA-SU（rG = 0.25）之间的遗传重叠量相似。独特的环境因素解释53%至76%的方差在这四个表型，而加性遗传因素解释17%至46%的方差。四种表型之间的协方差在很大程度上是由独特的环境因素解释的。共同遗传因素对所有四种表型都有显着影响，但它们解释了中等部分的协方差。
Psychological distress (PSYCH), somatic distress (SOMA), affective disorders (AD), and substance use (SU) frequently co-occur. The genetic relationship between PSYCH and SOMA, however, remains understudied. We examined the genetic and environmental influences on these two disorders and their comorbid AD and SU using structural equation modeling. Self-reported PSYCH and SOMA were measured in 1,548 twins using the two subscales of a 12-item questionnaire, the Somatic and Psychological Health Report. Its reliability and psychometric properties were examined. Six ADs, involvement of licit and illicit substance, and two SU disorders were obtained from 1,663–2,132 twins using the World Mental Health Composite International Diagnostic Interview and/or from an online adaption of the same. SU phenotypes (heritability: 49–79%) were found to be more heritable than the affective disorder phenotypes (heritability: 32–42%), SOMA (heritability: 25%), and PSYCH (heritability: 23%). We fit separate non-parametric item response theory models for PSYCH, SOMA, AD, and SU. The IRT scores were used as the refined phenotypes for fitting multivariate genetic models. The best-fitting model showed the similar amount of genetic overlap between PSYCH–AD (genetic correlation rG = 0.49) and SOMA–AD (rG =0.53), as well as between PSYCH–SU (rG = 0.23) and SOMA–SU (rG = 0.25). Unique environmental factors explained 53% to 76% of the variance in each of these four phenotypes, whereas additive genetic factors explained 17% to 46% of the variance. The covariance between the four phenotypes was largely explained by unique environmental factors. Common genetic factor had a significant influence on all the four phenotypes, but they explained a moderate portion of the covariance.