Rhodopeptins (Mer-N1033), novel cyclic tetrapeptides with antifungal activity from Rhodococcus sp.: I.: Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
Rhodopeptins (Mer-N1033), novel cyclic tetrapeptides with antifungal activity from Rhodococcus sp.: I.: Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
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DOI：
10.7164/antibiotics.52.695
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发表时间：
1999-08-01
影响因子：
3.3
通讯作者：
Yoshioka, T
中科院分区：
文献类型：
--
作者：
Chiba, H;Agematu, H;Yoshioka, T
从一株名为Rhodococcus sp. Mer-N1033的菌株中分离到5个新的环状四肽，命名为rhodopeptin C1、C2、C3、C4和B5。它们是一种新型的环状四肽，由一个β-氨基酸和三个常见的α-氨基酸组成。红肽素对白色念珠菌和新型隐球菌显示出高的体外抗真菌活性，而它们对细菌没有活性。
Five novel cyclic tetrapeptides, named rhodopeptin C1, C2, C3, C4 and B5, were isolated from a strain named Rhodococcus sp. Mer-N1033. They are a novel type of cyclic tetrapeptide composed of a beta-amino acid and three usual alpha-aminoacids. Rhodopeptins show high in vitro antifungal activity against Candida albicans and Crytococcus neoformans, whereas they show no activity against bacteria..