Long-term nonsteroidal antiinflammatory drug use and Helicobacter pylori infection.
Long-term nonsteroidal antiinflammatory drug use and Helicobacter pylori infection.
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长期使用非甾体抗炎药与幽门螺杆菌感染。
DOI：
10.1016/0016-5085(91)90665-8
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发表时间：
1991
期刊：
影响因子：
29.4
通讯作者：
Saeed,ZA
中科院分区：
文献类型：
--
作者：
Graham,DY;Lidsky,MD;Cox,AM;EvansJr,DJ;Evans,DG;Alpert,L;Klein,PD;Sessoms,SL;Michaletz,PA;Saeed,ZA
本研究调查服用非甾体抗炎药的患者是否比不服用非甾体抗炎药的同龄人更容易患幽门螺杆菌胃炎，以及服用非甾体抗炎药的患者是否也感染幽门螺杆菌。与未感染者相比，幽门螺杆菌感染者更容易出现消化不良、粘膜损伤或溃疡。进行了两项研究，一项是血清学研究，另一项是内窥镜研究，均针对长期接受非甾体抗炎药的关节炎患者。 H的存在。通过灵敏的酶联免疫吸附测定测试来鉴定幽门螺杆菌。 183 名患者参加了血清学研究，75 名患者参加了内窥镜研究。 H 的频率。幽门螺杆菌感染随着年龄的增长而增加，与非甾体抗炎药的使用无关； H 的年龄调整频率。关节炎患者的幽门螺杆菌感染情况与 351 名无关节炎的无症状个体的情况相似。 H 的频率。幽门螺杆菌感染从21-30岁年龄组的30.7%增加到61-75岁年龄组的73.4%。非甾体抗炎药引起的粘膜损伤（出血或糜烂）在没有幽门螺杆菌感染的患者中更为常见。幽门螺杆菌感染者与感染者相比，无幽门螺杆菌感染者与感染者出血率分别为61%和32%，糜烂率分别为57%和34%；仅出血频率差异有统计学意义，P<0.05）。患有幽门螺旋杆菌和不患有幽门螺杆菌的患者之间，在消化不良症状方面没有观察到差异。幽门螺杆菌感染。这些数据表明非甾体类抗炎药引起的胃十二指肠粘膜损伤不会增加幽门螺杆菌的易感性。幽门螺杆菌感染。
This study investigates whether patients who take nonsterodial antiinflammatory drugs are more likely to haveHelicobacter pylorigastritis than age-matched individuals who do not take nonsteroidal antiinflammatory drugs, and whether patients who take nonsteroidal antiinflammatory drugs who are also infected withH. pyloriare more likely to have dyspepsia, mucosal damage, or ulcers than those who are not infected. Two studies were performed, one serological and the other endoscopic, both in arthritis patients receiving nonsteroidal antiinflammatory drugs chronically. The presence ofH. pyloriwas identified with a sensitive enzyme-linked immunosorbent assay test. One hundred eighty-three patients participated in the serological study and 75 patients in the endoscopic study. The frequency ofH. pyloriinfection increased with age, independent of nonsteroidal antiinflammatory drug use; the age-adjusted frequency ofH. pyloriinfection in arthritis patients paralleled that of 351 asymptomatic individuals without arthritis. The frequency ofH. pyloriinfection increased from 30.7% in age group 21–30 years to 73.4% in age group 61–75 years. Nonsteroidal antiinflammatory drug-induced mucosal injury, either hemorrhages or erosions, was more frequent in those withoutH. pyloriinfection than with infection (61% vs. 32% for hemorrhages and 57% vs. 34% for erosions for those without and withH. pyloriinfection; only the difference in the frequency of hemorrhages was significant,P< 0.05). No difference was observed in the presence of dyspeptic symptoms between those with and withoutH. pyloriinfection. These data suggest that nonsteroidal antiinflammatory drug-induced damage to the gastroduodenal mucosa does not increase the susceptibility toH. pyloriinfection.