Information feedback of 18F-FDG PET/CT computer imaging combined with tumor markers on recurrence and metastasis of non-small cell lung cancer
Information feedback of 18F-FDG PET/CT computer imaging combined with tumor markers on recurrence and metastasis of non-small cell lung cancer
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DOI：
10.1016/j.jiph.2019.06.027
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发表时间：
2020-09-01
影响因子：
6.7
通讯作者：
Feng, Hua
中科院分区：
文献类型：
--
作者：
Mu, Yindong;Gui, Jinqiu;Feng, Hua
探讨肿瘤标志物联合F-18-FDG PET/CT计算机成像对非小细胞肺癌（NSCLC）复发转移的诊断价值或信息反馈。方法：选取2013年1月至2017年12月在牡丹江医科大学PET/CT计算机成像中心行全身F-18-FDG PET/CT计算机成像检查的非小细胞肺癌患者95例。通常，完成治疗和PET/CT计算机成像检查之间的间隔应至少为三个月。此外，所有患者在F-18-FDG PET/CT计算机成像前后均进行了血清CEA监测，其中70例同时进行了CYFRA21-1检测。每隔不到一周的时间用PET/CT检查肿瘤标志物，并将所有反馈结果与临床随访结果或最终病理进行比较。此外，所有入组患者随访6-12个月。结果：F-18-FDGPET/CT信息反馈评价NSCLC治疗后复发或转移的敏感性、准确性、特异性、阳性预测值和阴性预测值均优于常用肿瘤标志物，差异均有统计学意义（P < 0.05）。F-18-FDG PET/CT计算机成像联合肿瘤标志物检查对非小细胞肺癌治疗后复发和/或转移的判断均显著高于单独检查，信息反馈准确率差异有显著统计学意义（P < 0.05）。可见，肿瘤标志物诊断与F-18-FDG PET/CT诊断具有相关性，相关系数r = 0.63。血清CEA按不同水平分组，F-18-FDG PET/CT计算机成像诊断阳性率和准确率随CEA水平升高而升高。8例患者行F-18-FDG PET/CT双期检查，其中4例在治疗后诊断为复发或转移，均已检出。(c) 2019年由爱思唯尔有限公司代表沙特国王本阿卜杜勒阿齐兹健康科学大学出版。
To investigate the diagnostic value or information feedback of tumor markers combined with F-18-FDG PET/CT computer imaging on recurrence and metastasis of non-small cell lung cancer (NSCLC).Methods: From January 2013 to December 2017, 95 NSCLC patients undergoing systemic F-18-FDG PET/CT computer imaging examination at the PET/CT computer imaging center of Mudanjiang Medical University had been enrolled. Typically, the interval between the completion of treatment and PET/CT computer imaging examination should be at least three months. Besides, all patients had undergone serum CEA monitoring before and after F-18-FDG PET/CT computer imaging, and 70 of them had received CYFRA21-1 test at the same time. Tumor markers were examined with PET/CT at intervals of less than one week, and all the feedback results were compared with clinical follow-up results or final pathology. Additionally, all the enrolled patients were followed up for 6-12 months.Results: The sensitivity, accuracy, specificity, positive predictive value and negative predictive value of F-18-FDGPET/CT information feedback in evaluating recurrence or metastasis after NSCLC treatment were superior to those of common tumor markers, and the differences were statistically significant (P < 0.05). Those of F-18-FDG PET/CT computer imaging combined with tumor marker examination for the recurrence and/or metastasis after NSCLC treatment were remarkably higher than those of either individual examination, and the accuracy difference of information feedback had significant statistical significance (P < 0.05). Clearly, the diagnosis using tumor markers was correlated with that by F-18-FDG PET/CT imaging, and the correlation coefficient was r = 0.63. Moreover, serum CEA was grouped at different levels, and the positive rate and accuracy of F-18-FDG PET/CT computer imaging diagnosis were increased with the increase in CEA level. 8 patients had received F-18-FDG PET/CT dual-phase examination, among them, 4 were diagnosed with recurrence or metastasis after MSCLC treatment, and all of them had been detected. (c) 2019 Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences.