Rational spatio-temporal strategies for controlling a Chagas disease vector in urban environments
Rational spatio-temporal strategies for controlling a Chagas disease vector in urban environments
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DOI：
10.1098/rsif.2009.0479
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发表时间：
2010-07-06
影响因子：
3.9
通讯作者：
Plotkin, Joshua B.
中科院分区：
文献类型：
--
作者：
Levy, Michael Z.;Malaga Chavez, Fernando S.;Plotkin, Joshua B.
合理设计干预措施对于控制传染病至关重要，特别是在城市环境中。就南美锥虫病媒介Triatoma infestans而言，在杀虫剂效力减弱后，这种昆虫的返回阻碍了成功的防治。在这里，我们适应遗传算法，最初开发的旅行商问题，以改善时空设计的杀虫剂运动对T。在复杂的城市环境中。我们找到了一种策略，减少了预期的情况下，媒介返回34倍，目前的战略相比，顺序杀虫剂应用到空间上连续的社区。替代控制策略的相对成功取决于杀虫剂有效性的持续时间，并且在控制运动中出现不可预见的延迟时会出现混乱的波动。我们使用简化的模型来分析定性不同的时空策略的结果。我们的研究结果提供了一个详细的程序，以改善控制工作的城市恰加斯病媒介，以及一般的指导方针，以改善设计的干预措施，对其他疾病的代理人在复杂的环境。
The rational design of interventions is critical to controlling communicable diseases, especially in urban environments. In the case of the Chagas disease vector Triatoma infestans, successful control is stymied by the return of the insect after the effectiveness of the insecticide wanes. Here, we adapt a genetic algorithm, originally developed for the travelling salesman problem, to improve the spatio-temporal design of insecticide campaigns against T. infestans, in a complex urban environment. We find a strategy that reduces the expected instances of vector return 34-fold compared with the current strategy of sequential insecticide application to spatially contiguous communities. The relative success of alternative control strategies depends upon the duration of the effectiveness of the insecticide, and it shows chaotic fluctuations in response to unforeseen delays in a control campaign. We use simplified models to analyse the outcomes of qualitatively different spatio-temporal strategies. Our results provide a detailed procedure to improve control efforts for an urban Chagas disease vector, as well as general guidelines for improving the design of interventions against other disease agents in complex environments.