Electrophysiological signature of the interplay between habits and inhibition in response to smoking-related cues in individuals with a smoking habit: an ERP study
Electrophysiological signature of the interplay between habits and inhibition in response to smoking-related cues in individuals with a smoking habit: an ERP study
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DOI：
10.1101/2022.07.28.501841
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发表时间：
2022-08
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影响因子：
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通讯作者：
J. Dampuré;Paola Agudelo-Orjuela;Maartje van der Meij;D. Belin;H. Barber
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文献类型：
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作者：
J. Dampuré;Paola Agudelo-Orjuela;Maartje van der Meij;D. Belin;H. Barber
药物寻求的刚性，刺激约束的性质，其特征是物质使用障碍（SUD）与动机和早期注意力反射和抑制性反射系统的失调有关。然而，当药物配对的条件刺激CS促进SUD个体的寻找习惯的形成时，这些系统被药物配对的条件刺激CS参与的机制尚未阐明。本研究旨在从行为学和电生理学的角度来描述有吸烟习惯的个体中CSs招募的反射和反射系统之间相互作用的性质。为此，我们测量了20个人的行为表现和相关的ERP的吸烟习惯和20个控制，谁从来没有经常吸烟，在一个修改的去/不去的任务，在此期间，吸烟相关的CS，食欲，和中性的图片，无论是在第一人称或第三人称的视觉角度显示前250毫秒去/不去提示。我们发现，吸烟相关的线索选择性地影响早期的激励动机相关的注意力偏差（N2图片发病后），运动准备和行为抑制（去P3，不去P3和PC）的个人吸烟习惯时，只有从第一人称的角度来看。这些数据共同识别了在CS招募激励习惯期间反射和反射系统异常参与的神经签名，这些CS被呈现为好像它们是响应产生的，即，作为条件反射器。
The rigid, stimulus-bound nature of drug seeking that characterizes Substance-use disorder (SUD) has been related to a dysregulation of motivational and early attentional reflexive and inhibitory reflective systems. However, the mechanisms by which these systems are engaged by drug-paired conditioned stimuli CSs) when they promote the enactment of seeking habits in individuals with a SUD have not been elucidated. The present study aimed behaviorally and electrophysiologically to characterize the nature of the interaction between the reflexive and reflective systems recruited by CSs in individuals with a smoking habit. For this, we measured the behavioral performance and associated ERPs of 20 individuals with a smoking habit and 20 controls, who never smoked regularly, in a modified Go/NoGo task during which smoking-related CSs, appetitive, and neutral pictures, presented either in first-person or as a third-person visual perspective were displayed 250 ms before the Go/NoGo cue. We show that smoking-related cues selectively influence early incentive motivation-related attentional bias (N2 after picture onset), motor readiness and behavioral inhibition (Go-P3, NoGo-P3 and Pc) of individuals with a smoking habit only when presented from a first-person perspective. These data together identify the neural signature of the aberrant engagement of the reflexive and reflective systems during the recruitment of an incentive habit by CSs presented as if they had been response-produced, i.e., as conditioned reinforcers.