Control of fixation and saccades in humans with chronic lesions of oculomotor cortex.
Control of fixation and saccades in humans with chronic lesions of oculomotor cortex.
复制标题
控制患有动眼皮层慢性损伤的人类的注视和眼跳。
DOI：
10.1037/0894-4105.18.1.115
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Rafal,RobertD
中科院分区：
文献类型：
--
作者：
Machado,Liana;Rafal,RobertD
为了阐明皮质和皮质下动眼神经系统的动态相互作用，作者研究了涉及额叶或顶叶皮质的慢性单侧病变患者对注视和眼跳的反射性和策略性控制。他们测量了指示即将出现的目标的位置和去除注视刺激对 12 名额眼场 (FEF) 病变患者、9 名病变仅限于顶叶皮层的患者和 12 名神经健康对照患者的眼球运动朝向周边视觉目标的潜伏期的影响。他们发现，FEF 皮层的慢性损伤会破坏皮质-丘脑相互作用，导致对侧上丘活动减退，并失去对调节固定的内在丘脑回路的战略控制。
To elucidate the dynamic interactions of cortical and subcortical oculomotor systems, the authors investigated reflexive and strategic control over fixation and saccades in patients with chronic unilateral lesions that involved either frontal or parietal cortex. They measured the effects of indicating the location of the forthcoming target and removing the fixation stimulus on the latencies of eye movements toward a peripheral visual target in 12 patients with frontal eye field (FEF) lesions, 9 patients with lesions restricted to parietal cortex, and 12 neurologically healthy controls. They found that chronic damage to FEF cortex disrupts cortico-collicular interactions, resulting in hypoactivity in the contralesional superior colliculus and a loss of strategic control over the intrinsic collicular circuits that regulate fixation.