Intracellular trafficking and signaling in development.
Intracellular trafficking and signaling in development.
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DOI：
10.3410/b1-59
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发表时间：
2009-08-17
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影响因子：
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通讯作者：
Constam DB
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--
作者：
Constam DB
发育过程中的组织模式依赖于分泌的蛋白质和受体的细胞通讯，这些蛋白质和受体参与复杂的信号串扰，以上下文相关的方式诱导不同的细胞行为。在这里，我总结了对基本机制的最新见解，这些机制通过调节分泌和内吞过程中的运输决定来控制转化生长因子β、Wnt、Hedgehog和Notch蛋白的分布和活性。
Tissue patterning during development relies on cell communication by secreted proteins and receptors that engage in complex signaling crosstalk to induce distinct cell behaviors in a context-dependent fashion. Here I summarize recent insights into basic mechanisms that control the distribution and activities of transforming growth factor beta, Wnt, Hedgehog, and Notch proteins, by regulating trafficking decisions during secretion and endocytosis.