ACCURACY OF FROZEN-SECTION DIAGNOSIS OF MAMMOGRAPHICALLY DIRECTED BREAST BIOPSIES - RESULTS OF 1,490 CONSECUTIVE CASES
ACCURACY OF FROZEN-SECTION DIAGNOSIS OF MAMMOGRAPHICALLY DIRECTED BREAST BIOPSIES - RESULTS OF 1,490 CONSECUTIVE CASES
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DOI：
10.1097/00000478-199511000-00006
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发表时间：
1995-11-01
影响因子：
5.6
通讯作者：
BOSTWICK, DG
中科院分区：
文献类型：
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作者：
FERREIRO, JA;GISVOLD, JJ;BOSTWICK, DG
小原位乳腺癌和浸润性乳腺癌的术中冰冻切片诊断的准确性尚不确定。我们回顾了 1,439 名患者的 1,490 次连续线定位乳腺活检结果，这些患者在 Mayo Clinic 的冰冻切片检查中发现了不可触及的乳房 X 光检查异常。 3 年期间。乳腺X线异常包括良性钙化（61例）、不确定性钙化（422例）、令人担忧的钙化（54例）、界限清楚的结节（115例）、不规则结节（473例）、结构扭曲（52例）、不对称（39例）、界限清楚的结节伴钙化（12例）、不规则结节伴钙化（75 例）、结构扭曲伴钙化（35 例）和不对称伴钙化（12 例）。我们检测到 457 种癌，包括 135 种原位癌和 322 种浸润癌。浸润性癌平均直径1.07 cm（范围0.1~3.0 cm），其中1 cm以下191个（占59.3%）。在 77 例（占总数的 5.2%）中，诊断被推迟到永久切片。冰冻切片准确率为97.7%。 0.5%的病例出现假阴性诊断，无假阳性诊断。浸润癌直径与错误率没有相关性。这些结果表明，术中乳房X线照相定向乳腺活检冰冻切片可提供准确可靠的诊断。
The accuracy of intraoperative frozen-section diagnosis of small in situ and invasive breast cancers is uncertain. We reviewed the results of 1,490 consecutive wire-localized breast biopsies from 1,439 patients with nonpalpable mammographically detected abnormalities examined by frozen section at Mayo Clinic over a 3-year period. The mammographic abnormalities included benign calcifications (61 cases), indeterminate calcifications (422 cases), worrisome calcifications (54 cases), well-circumscribed nodules (115 cases), irregular nodules (473 cases), architectural distortions (52 cases), asymmetry (39 cases), well-circumscribed nodules with calcification (12 cases), irregular nodules with calcification (75 cases), architectural distortions with calcification (35 cases), and asymmetry with calcifications (12 cases). We detected 457 carcinomas, including 135 in situ and 322 invasive cancers. The invasive carcinomas had a mean diameter of 1.07 cm (range, 0.1-3.0 cm), including 191 with diameters of 1 cm or less (59.3% of cases). In 77 cases (5.2% of total), the diagnosis was deferred to permanent sections. Frozen-section accuracy was 97.7%. False-negative diagnoses were rendered in 0.5% of cases, and there were no false-positive diagnoses. There was no correlation of infiltrating carcinoma diameter and error rate. These results indicate that intraoperative frozen section of mammographically directed breast biopsies provides accurate and reliable diagnoses.