Pulse-Clamp Technique for Characterizing Neural-Stimulating Electrodes
Pulse-Clamp Technique for Characterizing Neural-Stimulating Electrodes
复制标题
用于表征神经刺激电极的脉冲钳位技术
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
J. Judy
中科院分区：
文献类型：
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作者：
A. Hung;David D. Zhou;R. Greenberg;I. Goldberg;J. Judy
需要可靠的测试方法来确保需要大量电荷注入和小电极尺寸的高分辨率神经刺激应用具有足够的电荷注入能力。设计并采用脉冲钳位电路来表征电极电荷存储能力，从而可以快速准确地比较不同的电极。该定制电路由商用元件组成，开关电荷噪声为 15 pC，开关时间为 1 μs。脉冲钳测量是在空气中 0.15 M 盐水溶液中的扁平铂电极上进行的，脉冲长度为 1 ms，电荷密度高达 1 mC/cm 2 。结果表明，安全电荷注入极限为 0.1 mC/cm 2 ，并且水解主导状态高于 0.5 mC/cm 2 。比较不同的电极尺寸表明电极的电荷存储能力与其表面积成正比。脉冲钳技术的可扩展性使其可用于准确量化表面改性的粗糙度。采用集成电路重点仿真的仿真程序来提取电极电容和电阻参数。这些参数可能会发生变化，很大程度上取决于注入的电荷密度。
A reliable test methsod is required to ensure adequate charge-injection capability for high-resolution neural-stimulation applications that demand both a large amount of charge injection and a small electrode size. A pulse-clamp circuit is designed and employed to characterize the electrode charge-storage capability that will allow different electrodes to be quickly and accurately compared. The custom circuit, which consists of commercial components, has a switching charge noise of 15 pC and a switching time of 1 μs. Pulse-clamp measurements are performed on flat platinum electrodes in 0.15 M saline solution in air with 1 ms long pulses at a charge density of up to 1 mC/cm 2 . Results indicate a safe charge-injection limit of 0.1 mC/cm 2 , and a hydrolysis-dominated regime above 0.5 mC/cm 2 . Comparing different electrode sizes indicates that the charge-storage capability of an electrode is proportional to its surface area. The scalability of the pulse-clamp technique allows it to be used to accurately quantify the roughness of a surface modification. Simulation program with integrated circuits emphasis simulation is used to extract the electrode capacitance and resistance parameters. These parameters, which can vary, depend strongly on the injected charge density.