Silica gel catalyzed synthesis of quinoxaline 1,4-dioxides under solvent-free conditions using microwave irradiation
Silica gel catalyzed synthesis of quinoxaline 1,4-dioxides under solvent-free conditions using microwave irradiation
复制标题
DOI：
10.3987/com-08-11588
复制
发表时间：
2009-04
期刊：
影响因子：
0.6
通讯作者：
T. Takabatake;Yusuke Sumiyoshi;Hiroaki Saito;S. Miyairi
中科院分区：
文献类型：
--
作者：
T. Takabatake;Yusuke Sumiyoshi;Hiroaki Saito;S. Miyairi
本文报道了在微波辐射下，无溶剂条件下简便、快速合成喹喔啉1，4-二氧化物的方法。将吸附在硅胶上的各种苯并氧化呋咱和β-酮酯或1，3-二酮在微波炉中加热两分钟，以高产率至优异的产率得到各种具有生物吸引力的喹喔啉1，4-二氧化物。硅胶不仅可以作为微波载体，而且可以作为催化剂和脱水剂。
We report on the simple and quick synthesis of quinoxaline 1,4-dioxides in solvent-free conditions under microwave irradiation. Heating of various benzofuroxans and β-ketoesters or 1,3-diketones adsorbed on silica gel in a microwave oven for two minutes affords diverse biologically attractive quinoxaline 1,4-dioxides in high to excellent yields. Silica gel functions not only as support using microwave but also as catalyst and dehydration reagent.