A PC-based graphical simulator for physiological pharmacokinetic models.
A PC-based graphical simulator for physiological pharmacokinetic models.
复制标题
基于 PC 的生理药代动力学模型图形模拟器。
DOI：
10.1016/0169-2607(95)01624-3
复制
发表时间：
1995
影响因子：
6.1
通讯作者：
Ebling,WF
中科院分区：
文献类型：
--
作者：
Wada,DR;Stanski,DR;Ebling,WF
Since many intravenous anesthetic drugs alter blood flows, physiologically-based pharmacokinetic models describing drug disposition may be time-varying. Using the commercially available programming software MATLAB, a platform to simulate time-varying physiological pharmacokinetic models was developed. The platform is based upon a library of pharmacokinetic blocks which mimic physiological structure. The blocks can be linked together flexibly to form models for different drugs. Because of MATLAB's additional numerical capabilities (e.g. non-linear optimization), the platform provides a complete graphical microcomputer-based tool for physiologic pharmacokinetic modeling.
