Direct Activation of the Large-Conductance Calcium-Activated Potassium Channel by Flavonoids Isolated from Sophora flavescens
Direct Activation of the Large-Conductance Calcium-Activated Potassium Channel by Flavonoids Isolated from Sophora flavescens
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DOI：
10.1248/bpb.b18-00250
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发表时间：
2018-08-01
影响因子：
2
通讯作者：
Park, Chul-Seung
中科院分区：
文献类型：
--
作者：
Lee, Sojung;Choi, Jae Sue;Park, Chul-Seung
In our recent study, we reported that kurarinone, one of the most abundant flavonoids found in the dry root of Sophora flavescens (Kushen), is a potent activator of the large-conductance Ca2+-activated K+ (BKca) channel. Herein, we isolated and characterized other flavonoid components from Kushen. Among the 13 compounds tested, six flavonoids were found to activate the BKca channel, three of which, 7,4'-dihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone, kuraridin, and kuraridinol, are new activators of the BKca channel.
